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Information Journal Paper

Title

Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats

Pages

  1179-1185

Abstract

 Objective(s): Association of adolescent Emotional stress (ES) with the incidence of Cardiovascular disease (CVD) at older age was investigated. Materials and Methods: 21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of their neighboring counterparts in the stress-box system in 5 successive days. 6 weeks after the last stress exposure, M-Mode echocardiographic assessment, qRT-PCR, and western blotting were performed in adult rats to determine the persistent effect of adolescent ES on cardiac performance and gene/protein expression levels of cardiac Natriuretic peptide receptor 3 (NPR3) as a biomarker of CVD. Results: Interventricular septum thicknesses in diastole (IVSd) increased from 0. 152± 0. 007 cm to 0. 197± 0. 016 cm (P<0. 05), left ventricular posterior wall thickness in diastole (LVPWd) significantly enlarged from 0. 169± 0. 006 cm to 0. 288± 0. 033 cm (P<0. 01), left ventricular posterior wall thickness in systole (LVPWs) enlarged from 0. 223± 0. 012 cm to 0. 318± 0. 038 cm (P<0. 05), left ventricular mass increased from 1. 000± 0. 024 g to 1. 283± 0. 084 g (P<0. 01), and mean Heart rate elevated from 229. 42± 6. 57 bpm to 280. 29± 10. 45 bpm (P<0. 01). Moreover, ES significantly upregulated the expression levels of cardiac NPR3 gene (P<0. 01) and protein (P<0. 01). Conclusion: The incidence of adult CVD seemed to be increased under the influence of adolescent ES. Consequently, we suggest that mental healthcare during adolescence would be a critical factor for adult CVD prevention.

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    APA: Copy

    MOUSAVI, MONIREH SADAT, IMANI, ALIREZA, Meknatkhah, Sogol, & Riazi, Gholamhossein. (2019). Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(10), 1179-1185. SID. https://sid.ir/paper/722552/en

    Vancouver: Copy

    MOUSAVI MONIREH SADAT, IMANI ALIREZA, Meknatkhah Sogol, Riazi Gholamhossein. Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(10):1179-1185. Available from: https://sid.ir/paper/722552/en

    IEEE: Copy

    MONIREH SADAT MOUSAVI, ALIREZA IMANI, Sogol Meknatkhah, and Gholamhossein Riazi, “Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 10, pp. 1179–1185, 2019, [Online]. Available: https://sid.ir/paper/722552/en

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