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Information Journal Paper

Title

The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes

Pages

  668-677

Abstract

 Objective(s): The aim of the present study was to assess the effects of Vitamin C (Vit C) on Hemolytic anemia induced by phenylhydrazine (PHZ). Materials and Methods: Twenty-four healthy male Mice were divided into four groups, randomly: Control group (0. 1 ml/day, normal slaine, IP), PHZ group that received only PHZ 8 mg/100 g/48 hr, IP, PHZ+Vit C group that received PHZ 8 mg/100 g/48 hr, IP and Vit C 100 mg/kg BW-1/day by gavage and Vit C group that received 100 mg/kg BW-1/day Vit C by gavage. After 35 days, germinal cells, RNA damage, sperm parameters, Testis malondialdehyde (MDA) content, serum total antioxidant capacity (TAC), pre-implantation embryo development and mRNA levels of cyclin D1 and c-myc in two-cell, and morula and blastocyst stages were assessed. Results: Vit C reduced the RNA damage, enhanced sperm quality, promoted pre-implantation embryo development and improved testicular antioxidant and endocrine status (P<0. 05). Vit C reduced cyclin D1 expression and up-regulated c-myc mRNA level in two-cell, morula, and blastocyst embryonic cells. Conclusion: Vit C enhanced the fertilizing potential by ameliorating the endocrine status, antioxidant capacity, and sperm quality. Finally, the cyclin D1 and c-myc gene expressions were regulated in PHZ+Vit C treated group that promoted the embryo development.

Cites

References

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APA: Copy

ANBARA, HOJAT, SHAHROOZ, RASOUL, RAZI, MAZDAK, MALEKINEJAD, HASSAN, & NAJAFI, GHOLAMREZA. (2018). The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(7), 668-677. SID. https://sid.ir/paper/721801/en

Vancouver: Copy

ANBARA HOJAT, SHAHROOZ RASOUL, RAZI MAZDAK, MALEKINEJAD HASSAN, NAJAFI GHOLAMREZA. The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(7):668-677. Available from: https://sid.ir/paper/721801/en

IEEE: Copy

HOJAT ANBARA, RASOUL SHAHROOZ, MAZDAK RAZI, HASSAN MALEKINEJAD, and GHOLAMREZA NAJAFI, “The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 7, pp. 668–677, 2018, [Online]. Available: https://sid.ir/paper/721801/en

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