Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAHANGIRFARD R.; RAJI A.R.; Moghaddam Jafari A.; NOURANI H.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:10 | Issue:2 Page(s): 2197-2205

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

402

Download:

104

Cites:

Information Journal Paper

Title

Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis

Author(s)

JAHANGIRFARD R. | RAJI A.R. | Moghaddam Jafari A. | NOURANI H. | Issue Writer Certificate

Keywords

HistomorphometryQ2

MiceQ2

TestisQ2

Titanium dioxideQ1

Vitamin EQ2

Abstract

Background & Objective: Nano Titanium dioxide particles (TiO2) are chemical compounds that are widely used in industrial and foodstuff such as cosmetics, toothpaste, colored materials, and non-fat milk whitening. Vitamin E (Vit E) is a dietary compound that functions as an antioxidant scavenging free radicals. The goal of this study was to carry out the protective effect of Vitamin E on Histomorphometry, oxidative stress factors and biochemical parameters as well as testosterone concentration. Materials & Methods: In the present study, 35 adult male Mice were divided into 7 control and experimental groups. The experimental groups received TiO2 at 2. 5, 5 and 10 doses, and the positive control group received Vitamin E (100 IU) mg/kg alone (by gavage tube). After treatment, animals were euthanized by cervical dislocation and testes samples were taken. The level of p<0. 05 was considered significant. Results: The results of Histomorphometry revealed that the weight of Testis and body, testicular capsule thickness, seminiferous tubules diameter, germinal epithelium height, spermiogenesis and meiotic indices were reduced while sertoli cells and repopulation index had no significant changes. Also, biochemical results showed the Malondialdehyde was enhanced and it diminished the total antioxidant capacity, catalase enzyme activity, protein content, as well as testosterone concentration. (p<0. 05). Conclusion: The TiO2 nanoparticles caused detrimental pathologic effects when used at the highest doses. However, Vitamin E could ameliorate the toxic effects of TiO2-induced on testicular tissue in experimental animals.

Cites

No record.

References

Cite

APA: Copy

JAHANGIRFARD, R., RAJI, A.R., Moghaddam Jafari, A., & NOURANI, H.. (2020). Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(2 ), 2197-2205. SID. https://sid.ir/paper/373223/en

Vancouver: Copy

JAHANGIRFARD R., RAJI A.R., Moghaddam Jafari A., NOURANI H.. Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;10(2 ):2197-2205. Available from: https://sid.ir/paper/373223/en

IEEE: Copy

R. JAHANGIRFARD, A.R. RAJI, A. Moghaddam Jafari, and H. NOURANI, “Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 2 , pp. 2197–2205, 2020, [Online]. Available: https://sid.ir/paper/373223/en

Related Journal Papers