Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAKHSHIZADEH MARYAM; Moshirian Toktam; ESMAILY HABIBOLLAH; RAJABI OMID; Nassirli Hooriyeh; SAZGARNIA AMENEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:10 Page(s): 1088-1092

Download Full-Text

View:

208

Download:

138

Cites:

Information Journal Paper

Title

Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement

Author(s)

Keywords

Sonophotodynamic –therapy

Photodynamic-herapy

Sonodynamic –therapy

Liposomal zinc

Phthalocyanine

Colon carcinoma

Abstract

Objective(s): Low penetration depth of light is the main defect of photodynamic therapy (PDT), which could be improved by sonodynamic therapy (SDT). In this study, a combination of PDT and SDT known as sonophotodynamic therapy (SPDT) was investigated using two reverse arrangements in CT26 tumor model. Materials and Methods: The Liposomal zinc Phthalocyanine was synthesized and characterized. It was then administered to CT26 tumor models as a sensitizer. The animal models were subjected to PDT, SDT, and the combined treatment in different groups. The doubling time for the survival of tumors and animals was considered as a measure to evaluate treatments efficacy. Results: In all treatment groups there was a significant decline in tumor volume 15 days after treatment compared to the main control group, but the optimum response was observed in the group receiving a combined treatment with the priority of PDT. 120 days after treatment, in the groups treated by PDT and SDT, the tumor shrank by 20%, while in the group receiving SPDT with PDT priority, 80% of tumors was recovered. No case of complete tumor progression was observed in SPDT group with SDT priority. This could be due to the pores created in cell membranes during ultrasound irradiation of the tumor, which removed the sensitizer molecules from the cells and reduced PDT efficacy in SPDT group with SDT priority. Conclusion: It seems that SPDT with PDT priority offers a more efficient alternative than each of PDT, SDT individually or SPDT with the reverse arrangement.

Cites

No record.

References

No record.

Cite

APA: Copy

BAKHSHIZADEH, MARYAM, Moshirian, Toktam, ESMAILY, HABIBOLLAH, RAJABI, OMID, Nassirli, Hooriyeh, & SAZGARNIA, AMENEH. (2017). Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(10), 1088-1092. SID. https://sid.ir/paper/722031/en

Vancouver: Copy

BAKHSHIZADEH MARYAM, Moshirian Toktam, ESMAILY HABIBOLLAH, RAJABI OMID, Nassirli Hooriyeh, SAZGARNIA AMENEH. Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(10):1088-1092. Available from: https://sid.ir/paper/722031/en

IEEE: Copy

MARYAM BAKHSHIZADEH, Toktam Moshirian, HABIBOLLAH ESMAILY, OMID RAJABI, Hooriyeh Nassirli, and AMENEH SAZGARNIA, “Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 10, pp. 1088–1092, 2017, [Online]. Available: https://sid.ir/paper/722031/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops