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Information Journal Paper

Title

Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model

Pages

  794-799

Abstract

 Objective(s): To investigate the systemic and local Immune status of two surgical rat models of Sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods: Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was performed. The percentage of CD4+ cells and the CD4+/CD8+ratio were determined by flow cytometry. Serum IgM and IgG levels were analyzed by ELISA. T-cells (CD3) and macrophages (CD68) in sciatic nerve tissue sections were identified through immunohistochemistry. Results: Compared to sham-operated controls, in rats that underwent nerve injury, the percentage of CD4+ cells and the CD4+/CD8+ ratio in the peripheral blood were significantly decreased 7 days after surgery, serum IgM levels were increased 14 days after surgery, and serum IgG levels were increased 21 days after surgery. There were a large number of CD3+ cells and a small number of CD68+ cells in sciatic nerve tissue sections 21 days after surgery, indicating T-cell and macrophage activation and infiltration. Local IgG deposition was also detected at the nerve injury site 21 days after surgery. Conclusion: Rat humoral and cellular Immune status changed following Sciatic nerve injury, particularly with regard to the cellular immune response at the nerve injury site.

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    • Cite

    APA: Copy

    Yuan, Wei, & Feng, Xinhong. (2016). Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(7), 794-799. SID. https://sid.ir/paper/722247/en

    Vancouver: Copy

    Yuan Wei, Feng Xinhong. Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(7):794-799. Available from: https://sid.ir/paper/722247/en

    IEEE: Copy

    Wei Yuan, and Xinhong Feng, “Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 7, pp. 794–799, 2016, [Online]. Available: https://sid.ir/paper/722247/en

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