مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

296
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

256
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

3

Information Journal Paper

Title

Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids

Pages

  282-289

Abstract

 Objective(s): Curcuminoids, comprising curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), are bioactive phytochemicals with numerous pharmacological effects. Oral Biological availability of Curcuminoids is low due to the low aqueous solubility and rapid metabolism. This study aimed at fabricating a nanomicellar Curcuminoid formula with enhanced pharmacokinetic properties. Materials and Methods: Curcuminoids nanoMicelles were prepared and characterized regarding particle properties, stability, release profile and pharmacokinetic parameters. Results: Encapsulation efficiency of Curcuminoids in nanoMicelles were 100%. Particle size analysis demonstrated a mean size of around 10 nm that remained stable for 24 months. Dissolution test showed the complete dissolution of encapsulated Curcuminoids from nanoMicelles within 20 min while the free Curcuminoids were poorly dissolved (approximately 7% after 60 min). The results of long-term (24 months) and accelerated (6 months) stability studies showed no changes in the size and content of nanoMicelles. The release studies in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) showed no release of Curcuminoids for at least 4 hours. In vivo study in BALB/c mice showed improved pharmacokinetic parameters including maximum plasma concentration (Cmax) and time to reach the maximum concentration (Tmax) with nanoMicelles as compared to free Curcuminoids and two other commercial products. Tmax for all the three Curcuminoid components was observed 30 min following oral administration. AUC of nanomicellar Curcuminoids was 59. 2 times more than free Curcuminoids. Conclusion: These data indicated that nanoMicelles could improve solubility, oral bioavailability and also the stability of Curcuminoids. Thus, they merit further investigation for enhancing pharmacological effects of Curcuminoids.

Cites

References

Cite

APA: Copy

Hatamipour, Mahdi, SAHEBKAR, AMIRHOSSEIN, Alavizadeh, Seyedeh Hoda, Dorri, Mahyar, & JAAFARI, MAHMOUD REZA. (2019). Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(3), 282-289. SID. https://sid.ir/paper/722254/en

Vancouver: Copy

Hatamipour Mahdi, SAHEBKAR AMIRHOSSEIN, Alavizadeh Seyedeh Hoda, Dorri Mahyar, JAAFARI MAHMOUD REZA. Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(3):282-289. Available from: https://sid.ir/paper/722254/en

IEEE: Copy

Mahdi Hatamipour, AMIRHOSSEIN SAHEBKAR, Seyedeh Hoda Alavizadeh, Mahyar Dorri, and MAHMOUD REZA JAAFARI, “Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 3, pp. 282–289, 2019, [Online]. Available: https://sid.ir/paper/722254/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button