مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

140
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

88
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

On the Benefit of Nanocurcumin on Aluminium Phosphideinduced Cardiotoxicity in a Rat Model

Pages

  111-121

Abstract

 Objective(s): Cardiotoxicity is considered the main cause of death in Aluminum Phosphide (ALP)-poisoned cases. Curcumin, an active ingredient of turmeric, is a potent protective polyphenol compound against cardiac diseases including Cardiotoxicity. This study aimed to examine the probable cardioprotection potential of nanomicelle curcumin in a Rat model of ALP-induced Cardiotoxicity. Methods: The Rats were orally intoxicated with ALP (12 mg/kg, p. o.; 1/4 LD50). In treatment groups, curcumin (50 mg/kg, i. p. ) and Nanocurcumin (10, 20 and 50 mg/ kg, i. p. ) were administered intraperitoneally 30 min following ALP administRation. Twenty four hrs subsequent to ALP intoxication, the hearts were dissected out for evaluation of Oxidative Stress and lipid peroxidation (LPO) markers such as thiol, reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH) levels, malondialdehyde (MDA) and the ferric reducing ability of plasma (FRAP). Results: In fact, ALP increased MDA as well as ROS and SOD levels. On the other hand, ALP significantly lowered thiol, GHS and FRAP markers. In contrast, Nanocurcumin successfully could reverse the increases in MDA as well as SOD, ROS and GSH. Simultaneously, it significantly enhanced thiol, GHS and FRAP markers. Moreover, curcumin markedly lowered MDA, ROS and SOD levels while increased thiol and GSH contents. Conclusions: Overall, the present data demonstRated the cardio-protective effects of Nanocurcumin in this model of cardiotixicity. Further, it suggested that this cardioprotecton is possibly mediated by the ability of Nanocurcumin to confront the Oxidative Stress and LPO resulting from ALP intoxication of the heart tissue.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    FAKHRAEI, NAHID, Hashemibakhsh, Reza, Abdolghafari, Amir Hossein, JAAFARI, MAHMOUD REZA, Mumtaz, Faiza, & MOUSAVI, SEYYEDEH ELAHEH. (2019). On the Benefit of Nanocurcumin on Aluminium Phosphideinduced Cardiotoxicity in a Rat Model. NANOMEDICINE RESEARCH JOURNAL, 4(2), 111-121. SID. https://sid.ir/paper/769470/en

    Vancouver: Copy

    FAKHRAEI NAHID, Hashemibakhsh Reza, Abdolghafari Amir Hossein, JAAFARI MAHMOUD REZA, Mumtaz Faiza, MOUSAVI SEYYEDEH ELAHEH. On the Benefit of Nanocurcumin on Aluminium Phosphideinduced Cardiotoxicity in a Rat Model. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(2):111-121. Available from: https://sid.ir/paper/769470/en

    IEEE: Copy

    NAHID FAKHRAEI, Reza Hashemibakhsh, Amir Hossein Abdolghafari, MAHMOUD REZA JAAFARI, Faiza Mumtaz, and SEYYEDEH ELAHEH MOUSAVI, “On the Benefit of Nanocurcumin on Aluminium Phosphideinduced Cardiotoxicity in a Rat Model,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 2, pp. 111–121, 2019, [Online]. Available: https://sid.ir/paper/769470/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button