Studying humane endpoints in a rat model of mammary carcinogenesis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

I Faustino Rocha Ana; Ginja Mario; Ferreira Rita; Oliveira Paula A

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:6 Page(s): 643-649

Download Full-Text

View:

222

Download:

245

Cites:

Information Journal Paper

Title

Studying humane endpoints in a rat model of mammary carcinogenesis

Author(s)

I Faustino Rocha Ana | Ginja Mario | Ferreira Rita | Oliveira Paula A | Issue Writer Certificate

Keywords

Chemically-induced

Humane endpoints

Mammary cancer

N-methyl-N-nitrosourea

Rat

Welfare

Abstract

Objective(s): The present work intended to clearly define the most adequate Humane endpoints in an experimental assay of mammary carcinogenesis in Rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal Welfare/distress during an experimental assay of Chemically-induced mammary carcinogenesis in female Rats. Results: Fourteen animals developed at least one mammary tumor with a diameter >35 mm. No animals exhibited alteRations in the remaining parameters that implied their early sacrifice. Statistically significant changes were not observed in the quantitative parameters like the hematocrit and urine specific gravity among groups, not being valuable for the assessment of the health status of animals included in an assay of mammary carcinogenesis for 18 weeks. The remaining Humane endpoints seemed to be helpful to monitor the animals’ health status. Conclusion: The alteRation in only one humane endpoint (mammary tumor dimensions) does not imply the animals’ sacrifice; the endpoints should be evaluated in conjunction, in order to define the most adequate time in which the animals should be sacrificed.

Cites

No record.

References

Cite

APA: Copy

Ginja, Mario, Ferreira, Rita, & Oliveira, Paula A. (2019). Studying humane endpoints in a rat model of mammary carcinogenesis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 643-649. SID. https://sid.ir/paper/722354/en

Vancouver: Copy

Ginja Mario, Ferreira Rita, Oliveira Paula A. Studying humane endpoints in a rat model of mammary carcinogenesis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):643-649. Available from: https://sid.ir/paper/722354/en

IEEE: Copy

Mario Ginja, Rita Ferreira, and Paula A Oliveira, “Studying humane endpoints in a rat model of mammary carcinogenesis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 643–649, 2019, [Online]. Available: https://sid.ir/paper/722354/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops