Early oleate deficiency leads to severe defects in fetal rat liver development

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MOHAMMADZADEH FATEMEH; ALIHEMMATI ALIREZA; Pirpour Tazehkand Abbas; DARABI MASOUD; MEHDIZADEH AMIR

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:9 Page(s): 1010-1015

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Title

Early oleate deficiency leads to severe defects in fetal rat liver development

Author(s)

Keywords

Development

Embryo

Hepatocytes

Monounsaturated fatty acids

Pregnancy

Abstract

Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic Development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat liver Development. Materials and Methods: Female Wistar rats with an average weight of 200± 20 g were subjected to this study. After mating, pregnant rats were divided into three groups and gavaged with the vehicle, MF 438 or MF-438 plus oleate from day 3 of Pregnancy for five days. Obtained fetuses were sacrificed and the liver tissues were retrieved. Hepatic morphological index, biochemical markers, and gene expression of hepatic Development markers were analyzed using Hematoxylin-Eosine, spectrometry, and real-time PCR techniques, respectively. Results: Relatively, deficient morphological indices and hepatic maturation markers were observed in fetus livers of the inhibitor-treated group. In comparison to the other two groups, total hepatic protein and glycogen content were increased with treatment of MF-438 plus oleate. Hepatocyte nuclear factor 1α , alpha fetoprotein, albumin, and cytochrome P450 gene expression were also significantly increased in the group treated with both MF-438 and oleate. Conclusion: Our data indicate that oleate availability during early Embryo Development is linked with fetal rat liver Development.

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APA: Copy

MOHAMMADZADEH, FATEMEH, ALIHEMMATI, ALIREZA, Pirpour Tazehkand, Abbas, DARABI, MASOUD, & MEHDIZADEH, AMIR. (2019). Early oleate deficiency leads to severe defects in fetal rat liver development. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(9), 1010-1015. SID. https://sid.ir/paper/722399/en

Vancouver: Copy

MOHAMMADZADEH FATEMEH, ALIHEMMATI ALIREZA, Pirpour Tazehkand Abbas, DARABI MASOUD, MEHDIZADEH AMIR. Early oleate deficiency leads to severe defects in fetal rat liver development. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(9):1010-1015. Available from: https://sid.ir/paper/722399/en

IEEE: Copy

FATEMEH MOHAMMADZADEH, ALIREZA ALIHEMMATI, Abbas Pirpour Tazehkand, MASOUD DARABI, and AMIR MEHDIZADEH, “Early oleate deficiency leads to severe defects in fetal rat liver development,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 9, pp. 1010–1015, 2019, [Online]. Available: https://sid.ir/paper/722399/en

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