مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran

Pages

  38-42

Abstract

 Objective(s): Resistance to carbapenems is the principal reason for the continuing utilization of Colistin as a last resort choice for treating the infections resulted from multidrug carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates. The assessment of antimicrobial resistance pattern, the prevalence of carbapenem-resistance determinants, and molecular epidemiology of Colistin-resistant isolates among CRPA strains were the aims of the present research. Materials and Methods: The current cross-sectional research was conducted on 269 CRPA isolates collected from various clinical samples from 2013 to 2016. After performing identification tests, disk diffusion as well as MIC methods were used for testing sensitivity to the antibiotics. Modified Hodge Test (MHT) was utilized to produce carbapenemase. PCR technique identified beta-lactamase classes A, B, and D genes. Results: In total, from 269 CRPA, five isolates (1. 3%) were resistant to Colistin. It was found that blaNDM-1, blaIMP-1, blaVIM-2, and blaOXA-10 genes were present in 40%, 40%, 20%, and 100% of Colistin-resistant isolates, respectively. DLST type 25-11 is a significant cluster of Colistin-resistant P. aeruginosa isolates. Conclusion: The appearance of Colistin-resistant isolates in CRPA carrying blaNDM-1 with multiple carbapenem-resistant genes shows the great problem in the treatment of P. aeruginosa infections.

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    APA: Copy

    FARAJZADEH SHEIKH, AHMAD, SHAHIN, MOJTABA, SHOKOOHIZADEH, LEILI, Halaji, Mehrdad, SHAHCHERAGHI, FERESHTEH, & GHANBARI, FAHIMEH. (2019). Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(1), 38-42. SID. https://sid.ir/paper/722426/en

    Vancouver: Copy

    FARAJZADEH SHEIKH AHMAD, SHAHIN MOJTABA, SHOKOOHIZADEH LEILI, Halaji Mehrdad, SHAHCHERAGHI FERESHTEH, GHANBARI FAHIMEH. Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(1):38-42. Available from: https://sid.ir/paper/722426/en

    IEEE: Copy

    AHMAD FARAJZADEH SHEIKH, MOJTABA SHAHIN, LEILI SHOKOOHIZADEH, Mehrdad Halaji, FERESHTEH SHAHCHERAGHI, and FAHIMEH GHANBARI, “Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 1, pp. 38–42, 2019, [Online]. Available: https://sid.ir/paper/722426/en

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