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Information Journal Paper

Title

Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats

Pages

  1289-1296

Abstract

 Objective(s): The present study was conducted to examine the effect of Sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats. Materials and Methods: Male Wistar rats (n = 40) were assigned to four groups (10 animals each): sham surgery (Sham), 6-hydroxydopamine (6-OHDA)-lesioned (OH), 6-OHDA-lesioned plus grid control (OH+GC), 6-OHDA-lesioned plus SD (OH+SD). Parkinson’ s disease (PD) model was induced by the unilateral intra-striatal infusion of 6-OHDA (10 μ g/rat). SD (4 hr/day, for 14 days) was induced using a multiple platforms water tank. On the last day of interventions, animals were subjected to open field test for horizontal motor performance assessment. Also, brain-derived neurotrophic factor (BDNF), Bcl-2 and Bax were assessed in the striatum of study groups. Results: SD obscured the motor deficits of PD animals observed in open field test. BDNF level and Bcl2/Bax ratio significantly increased in the OH group, and SD reduced their levels in the PD animals. Conclusion: SD suppressed the anti-apoptotic compensatory responses in the striatum; therefore, it may accelerate continual neuronal cell death in PD.

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    APA: Copy

    AHMADIAN, NAHID, MAHMOUDI, JAVAD, TALEBI, MAHNAZ, Molavi, Leila, SADIGH ETEGHAD, SAEED, Rostrup, Egill, & ZIAEE, MOJTABA. (2018). Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(12), 1289-1296. SID. https://sid.ir/paper/722546/en

    Vancouver: Copy

    AHMADIAN NAHID, MAHMOUDI JAVAD, TALEBI MAHNAZ, Molavi Leila, SADIGH ETEGHAD SAEED, Rostrup Egill, ZIAEE MOJTABA. Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(12):1289-1296. Available from: https://sid.ir/paper/722546/en

    IEEE: Copy

    NAHID AHMADIAN, JAVAD MAHMOUDI, MAHNAZ TALEBI, Leila Molavi, SAEED SADIGH ETEGHAD, Egill Rostrup, and MOJTABA ZIAEE, “Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 12, pp. 1289–1296, 2018, [Online]. Available: https://sid.ir/paper/722546/en

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