مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

206
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

118
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro

Pages

  1161-1166

Abstract

 Objective(s): A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods: In this study, we used the Oncomine™ database to determine the expression patterns of RHBDD1 in normal and breast cancer tissues. We performed lentiviral transfection of RHBDD1-specific Small interfering RNA into the breast cancer cell lines ZR-75-30 and MDA-MB-231 in order to investigate the effects of RHBDD1 deficiency on breast cancer metastasis. Results: We found that knockdown of RHBDD1 inhibited breast cancer cell migration and invasion in vitro. Moreover, knockdown of RHBDD1 promoted epithelial– mesenchymal transition (EMT) by suppressing the expression of MPP2, MPP9, fibronectin 1, vimentin, SRY-box 2, zinc finger E-box binding homeobox 1, and snail family transcriptional repressor 1, and promoting the expression of cadherin 1. Additionally, knockdown of RHBDD1 inhibited the protein expression and phosphorylation of Akt. Conclusion: Our data indicate that RHBDD1 overexpression may promote breast cancer metastasis via the regulation of EMT, suggesting that RHBDD1 may be an important regulator of breast cancer metastasis.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Huang, Chunjun, Ji, Xiaochun, Peng, Yinyin, Wu, Minghua, Wu, Weizhu, LUO, YONG, Cheng, Gaoxiang, & Zhu, Ye. (2018). Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1161-1166. SID. https://sid.ir/paper/722623/en

    Vancouver: Copy

    Huang Chunjun, Ji Xiaochun, Peng Yinyin, Wu Minghua, Wu Weizhu, LUO YONG, Cheng Gaoxiang, Zhu Ye. Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1161-1166. Available from: https://sid.ir/paper/722623/en

    IEEE: Copy

    Chunjun Huang, Xiaochun Ji, Yinyin Peng, Minghua Wu, Weizhu Wu, YONG LUO, Gaoxiang Cheng, and Ye Zhu, “Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1161–1166, 2018, [Online]. Available: https://sid.ir/paper/722623/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button