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Information Journal Paper

Title

Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell

Pages

  262-266

Keywords

Factor forkhead box O1-(FOXO1) 

Abstract

 Objective(s): JiangTangXiaoKe (JTXK) granule, a Chinese traditional herbal formula, has been clinically used and demonstrated to be beneficial in controlling high glucose and to relieve the symptoms of Type 2 diabetes mellitus patients for decades. In this study, we explored how Loganin, one of the components in JTXK granule, mediated the anti-diabetic effect. Materials and Methods: We generate a cell model with the dysfunction of insulin secretion by overexpression FOXO1 in INS-1 cells. MTT method was used to detect cytotoxicity after treated with Loganin. ELISA analysis was used to examine insulin secretion. The expression levels of FOXO1 and Akt were evaluated by Western blot. Results: Treatment with Loganin did not change the expression level of FOXO1 in INS-1 cells, but increased phosphorylation of FOXO1 and inhibited the nuclear translocation and accumulation of FOXO1, which improved the insulin secretion of the cells. Mechanistically, we found PI3K/Akt signaling pathway involved in these effects, which were blocked by an Akt inhibitor, LY294002. Conclusion: Loganin mediated the subcellular distribution of FOXO1 via PI3K/Akt signaling pathway, which protected the function of insulin secretion in islet INS-1 cells.

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    Cite

    APA: Copy

    Mo, Fang Fang, Liu, Hai Xia, ZHANG, YI, Hua, Jing, Zhao, Dan Dan, An, Tian, Zhang, Dong Wei, Tian, Tian, & Gao, Si Hua. (2019). Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(3), 262-266. SID. https://sid.ir/paper/722686/en

    Vancouver: Copy

    Mo Fang Fang, Liu Hai Xia, ZHANG YI, Hua Jing, Zhao Dan Dan, An Tian, Zhang Dong Wei, Tian Tian, Gao Si Hua. Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(3):262-266. Available from: https://sid.ir/paper/722686/en

    IEEE: Copy

    Fang Fang Mo, Hai Xia Liu, YI ZHANG, Jing Hua, Dan Dan Zhao, Tian An, Dong Wei Zhang, Tian Tian, and Si Hua Gao, “Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 3, pp. 262–266, 2019, [Online]. Available: https://sid.ir/paper/722686/en

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