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Information Journal Paper

Title

Low‑ dose intravenous acetaminophen versus oral ibuprofen for the closure of patent ductus arteriosus in premature neonates

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  0-0

Abstract

 Background: Patent ductus arteriosus (PDA) is a common disease in premature neonates, which could occur in up to 50% of the neonates weighting <1000 g. PDA might induce hemodynamic and respiratory disorders and increase mortality and morbidity. This study aimed to compare the effectiveness of oral ibuprofen and a low dose of intravenous Acetaminophen in the management of PDA. Materials and Methods: This randomized double‑ blind clinical trial was conducted on the preterm neonates with an equal gestational age of <34 weeks and weight of >1000 g with symptomatic PDA, who were admitted in Shahid Beheshti and Al‑ Zahra Hospitals Affiliated to Isfahan University of Medical Sciences, Iran. In total, 40 preterm neonates were examined, 20 of whom received 15 mg/ kg/6 h of intravenous Acetaminophen for 2 days and 20 infants received 10 mg/kg of intravenous ibuprofen on the 1st day and 5 mg/kg for the next 2 days, and the results include vital signs and echocardiography findings were compared. Results: In the Acetaminophen and ibuprofen groups, 16 (80%) and 17 neonates (85%) responded (PDA closure rate) to the treatment, respectively (P = 0. 68). Furthermore, Acetaminophen and ibuprofen have a similar effect on vital signs. Both drugs did not change in blood pressure, but they reduced the respiratory rate and heart rate after treatment. Conclusion: Low‑ dose Acetaminophen compared to ibuprofen has an equal effectiveness in the closure of PDA.

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    APA: Copy

    GHADERIAN, MEHDI, ARMANIAN, AMIR MOHAMMAD, SABRI, MOHAMMAD REZA, & Montaseri, Mojtaba. (2019). Low‑ dose intravenous acetaminophen versus oral ibuprofen for the closure of patent ductus arteriosus in premature neonates. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 24(2), 0-0. SID. https://sid.ir/paper/722743/en

    Vancouver: Copy

    GHADERIAN MEHDI, ARMANIAN AMIR MOHAMMAD, SABRI MOHAMMAD REZA, Montaseri Mojtaba. Low‑ dose intravenous acetaminophen versus oral ibuprofen for the closure of patent ductus arteriosus in premature neonates. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2019;24(2):0-0. Available from: https://sid.ir/paper/722743/en

    IEEE: Copy

    MEHDI GHADERIAN, AMIR MOHAMMAD ARMANIAN, MOHAMMAD REZA SABRI, and Mojtaba Montaseri, “Low‑ dose intravenous acetaminophen versus oral ibuprofen for the closure of patent ductus arteriosus in premature neonates,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 24, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/722743/en

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