مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Immunogenicity of chimeric MUC1-HER2 vaccine against breast cancer in mice

Pages

  26-32

Abstract

 Objective(s): Breast cancer is one of the most common cancers in the world and is on the increase. MUC1 and HER2 as tumor-associated antigens (TAAs) are abnormally expressed to some extent in 75– 80% of Breast cancers. In our present research, a novel chimeric MUC1-HER2 (HM) protein was designed and used to study whether an immune response can be generated against these TAAs. In vitro analysis of the HER2-MUC1 construct confirmed the co-expression of MUC1 and HER2. Materials and Methods: BALB/c mice were immunized with this novel chimeric protein. The humoral immune response was assessed by enzyme-linked immunosorbent assay (ELISA). Then, BALB/c mice were injected subcutaneously 2×105 4T1-MUC1-HER2 tumor cells. Subsequently, tumor size and tumor necrosis measurements, MTT, cytokines assay and survival test were performed. Results: The results implied a critical role of HER2 and MUC1 antibodies in vaccination against Breast cancer. This engineered protein can be a good Vaccine to stop Breast cancer. Conclusion: The results implied a critical role of HER2 and MUC1 antibodies in vaccination against Breast cancer. This engineered protein can be a good Vaccine to stop Breast cancer.

Cites

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    • Cite

    APA: Copy

    Gheybi, Elaheh, HATEF SALMANIAN, ALI, IMANI FOOLADI, ABBAS ALI, SALIMIAN, JAFAR, MAHMOODZADEH HOSSEINI, HAMIDEH, HALABIAN, RAHELEH, & AMANI, JAFAR. (2018). Immunogenicity of chimeric MUC1-HER2 vaccine against breast cancer in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(1), 26-32. SID. https://sid.ir/paper/722759/en

    Vancouver: Copy

    Gheybi Elaheh, HATEF SALMANIAN ALI, IMANI FOOLADI ABBAS ALI, SALIMIAN JAFAR, MAHMOODZADEH HOSSEINI HAMIDEH, HALABIAN RAHELEH, AMANI JAFAR. Immunogenicity of chimeric MUC1-HER2 vaccine against breast cancer in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(1):26-32. Available from: https://sid.ir/paper/722759/en

    IEEE: Copy

    Elaheh Gheybi, ALI HATEF SALMANIAN, ABBAS ALI IMANI FOOLADI, JAFAR SALIMIAN, HAMIDEH MAHMOODZADEH HOSSEINI, RAHELEH HALABIAN, and JAFAR AMANI, “Immunogenicity of chimeric MUC1-HER2 vaccine against breast cancer in mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 1, pp. 26–32, 2018, [Online]. Available: https://sid.ir/paper/722759/en

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