مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats

Pages

  221-227

Abstract

 Objective(s): Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The Cardioprotective effect of Royal jelly was investigated on Paclitaxel-induced damages. Materials and Methods: Adult male Wistar rats were divided into control and test groups (n=8). The test group was assigned into five subgroups; 4 groups, along with Paclitaxel administration (7. 5 mg/kg BW, weekly), received various doses of Royal jelly (50, 100, and 150 mg/kg BW) for 28 consecutive days. The last group received only Royal jelly at 100 mg/kg. In addition to oxidative and nitrosative stress biomarkers, the creatine kinase (CK-BM) level was also determined. To show the Cardioprotective effect of Royal jelly on Paclitaxel-induced damages, histopathological examinations were conducted. Results: Royal jelly lowered the Paclitaxel-elevated malondialdehyde and nitric oxide levels in the heart. Royal jelly could also remarkably reduce the Paclitaxel-induced cardiac biomarker of creatine kinase (CK-BM) level and pathological injuries such as diffused edema, hemorrhage, congestion, hyaline exudates, and necrosis. Moreover, Royal jelly administration in a dose-dependent manner resulted in a significant (P<0. 05) increase in the Paclitaxel-reduced total Antioxidant capacity. Conclusion: Our data suggest that the Paclitaxel-induced histopathological and biochemical alterations could be protected by the Royal jelly administration. The Cardioprotective effect of Royal jelly may be related to the suppression of oxidative and nitrosative stress.

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    APA: Copy

    MALEKINEJAD, HASSAN, Ahsan, Sima, Delkhosh Kasmaie, Fatemeh, CHERAGHI, HADI, REZAEI GOLMISHEH, ALI, & Janbaz Acyabar, Hamed. (2016). Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(2), 221-227. SID. https://sid.ir/paper/723066/en

    Vancouver: Copy

    MALEKINEJAD HASSAN, Ahsan Sima, Delkhosh Kasmaie Fatemeh, CHERAGHI HADI, REZAEI GOLMISHEH ALI, Janbaz Acyabar Hamed. Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(2):221-227. Available from: https://sid.ir/paper/723066/en

    IEEE: Copy

    HASSAN MALEKINEJAD, Sima Ahsan, Fatemeh Delkhosh Kasmaie, HADI CHERAGHI, ALI REZAEI GOLMISHEH, and Hamed Janbaz Acyabar, “Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 2, pp. 221–227, 2016, [Online]. Available: https://sid.ir/paper/723066/en

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