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Information Journal Paper

Title

The contribution of S100B to the glioprotective effects of valproic and arundic acids

Pages

  557-562

Abstract

 Objective(s): Valproic and Arundic acids are Astrocytes-modulating agents with potential effects in the treatment of Alzheimer’ s disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective effects of valproic and Arundic acids against Amyloid-β-peptide (Aβ )-induced glial death and contribution of S100B to the glioprotective effects of these agents in an astrocytic culture. Materials and Methods: We used Aβ 25– 35 at a concentration of 200 μ M in 1321N1 astrocyte cells. We treated the cells with Valproic Acid (0. 5 and 1 mM) and/or Arundic acid 50 μ M for 24 hr. Methylthiazolyldiphenyltetrazolium bromide (MTT) test was used to measure cell viability. The intracellular and extracellular S100B levels were measured using an ELISA kit. The data were analyzed using one-way analysis of variance followed by the Tukey’ s test. Results: Aβ (200 μ M) decreased the cell viability compared to the control group (P<0. 001). Valproic Acid (0. 5 and 1 mM) and Arundic acid (50 μ M) ameliorated the gliotoxic effects of Aβ (P<0. 05). The Aβ-treated group had higher S100B levels (both intracellular and extracellular) compared to the negative control groups (P<0. 001). Arundic and Valproic Acids (0. 5 and 1 mM) decreased both the intracellular and extracellular S100B levels compared to the Aβ-treated group (P<0. 001). Conclusion: By considering homeostatic and neuroprotective functions of astrocyte, the astroprotective effects and the attenuation of S100B level may be responsible, at least in part, for the beneficial effects of valproic and Arundic acids in AD.

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    APA: Copy

    KESHAVARZ, MOJTABA, Farrokhi, Majid Reza, AMIRI, ATENA, HOSSEINI, MAHSHID, & HOSSEINI, MAHSHID. (2019). The contribution of S100B to the glioprotective effects of valproic and arundic acids. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(5), 557-562. SID. https://sid.ir/paper/723364/en

    Vancouver: Copy

    KESHAVARZ MOJTABA, Farrokhi Majid Reza, AMIRI ATENA, HOSSEINI MAHSHID, HOSSEINI MAHSHID. The contribution of S100B to the glioprotective effects of valproic and arundic acids. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(5):557-562. Available from: https://sid.ir/paper/723364/en

    IEEE: Copy

    MOJTABA KESHAVARZ, Majid Reza Farrokhi, ATENA AMIRI, MAHSHID HOSSEINI, and MAHSHID HOSSEINI, “The contribution of S100B to the glioprotective effects of valproic and arundic acids,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 5, pp. 557–562, 2019, [Online]. Available: https://sid.ir/paper/723364/en

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