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Information Journal Paper

Title

Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study

Pages

  1044-1049

Abstract

 Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The Metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the Saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic Hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups. Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways. Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.

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    APA: Copy

    GILANY, KAMBIZ, MOHAMADKHANI, ASHRAF, Chashmniam, Saeed, SHAHNAZARI, PARISA, AMINI, MEHDI, ARJMAND, BABAK, MALEKZADEH, GHOLAMREZA, & Nobakht Motlagh Ghoochani, Bibi Fatemeh. (2019). Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(9), 1044-1049. SID. https://sid.ir/paper/723421/en

    Vancouver: Copy

    GILANY KAMBIZ, MOHAMADKHANI ASHRAF, Chashmniam Saeed, SHAHNAZARI PARISA, AMINI MEHDI, ARJMAND BABAK, MALEKZADEH GHOLAMREZA, Nobakht Motlagh Ghoochani Bibi Fatemeh. Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(9):1044-1049. Available from: https://sid.ir/paper/723421/en

    IEEE: Copy

    KAMBIZ GILANY, ASHRAF MOHAMADKHANI, Saeed Chashmniam, PARISA SHAHNAZARI, MEHDI AMINI, BABAK ARJMAND, GHOLAMREZA MALEKZADEH, and Bibi Fatemeh Nobakht Motlagh Ghoochani, “Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 9, pp. 1044–1049, 2019, [Online]. Available: https://sid.ir/paper/723421/en

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