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Information Journal Paper

Title

S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κ B pathways

Pages

  194-201

Abstract

 Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of Scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with Scleroderma was determined. Different concentrations of Bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κ B) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined. Results: The content of S100A9 in the skin tissues of mice with Scleroderma was determined. Different concentrations of BLM and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κ B) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined. Conclusion: S100A9 aggravates dermal fibrosis in BLM-induced Scleroderma (BIS) mice, and its mechanisms might be mediated by RAGE, ERK1/2, and NF-κ B pathway.

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    • Cite

    APA: Copy

    Xu, Xue, Chen, Zhiyong, Zhu, Xiaoxia, Wang, Dandan, Liang, Jun, Zhao, Cheng, Feng, Xuebing, Wang, Jiucun, Zou, Hejian, & Sun, Lingyun. (2018). S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κ B pathways. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(2), 194-201. SID. https://sid.ir/paper/723746/en

    Vancouver: Copy

    Xu Xue, Chen Zhiyong, Zhu Xiaoxia, Wang Dandan, Liang Jun, Zhao Cheng, Feng Xuebing, Wang Jiucun, Zou Hejian, Sun Lingyun. S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κ B pathways. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(2):194-201. Available from: https://sid.ir/paper/723746/en

    IEEE: Copy

    Xue Xu, Zhiyong Chen, Xiaoxia Zhu, Dandan Wang, Jun Liang, Cheng Zhao, Xuebing Feng, Jiucun Wang, Hejian Zou, and Lingyun Sun, “S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κ B pathways,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 2, pp. 194–201, 2018, [Online]. Available: https://sid.ir/paper/723746/en

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