Effect of sodium hydrosulfide on mRNA expression of prostaglandin E2 receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats

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MARD SEYYED ALI; Mahini Simin; DIANAT MAHIN; FARBOOD YAGHOOB

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:2 Page(s): 145-149

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Title

Effect of sodium hydrosulfide on mRNA expression of prostaglandin E2 receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats

Author(s)

MARD SEYYED ALI | Mahini Simin | DIANAT MAHIN | FARBOOD YAGHOOB | Issue Writer Certificate

Keywords

Mucosal acidification

Prostaglandin E2

receptors

Rat

Sodium hydrosulfide

Abstract

Prostaglandins have been shown to mediate the gastro-protective effect of Sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of Prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors in response to Mucosal acidification and distention-induced gastric acid secretion in Rats. Materials and Methods: Fasted Rats were randomly assigned into 4 groups (n=6/group). They were control, and NaHS-treated groups. To evaluate the effect of NaHS on mucosal mRNA expression of EPs receptors, the gastric mucosa exposed to stimulated gastric acid output and Mucosal acidification. The pylorus sphincter catheterized for instillation of isotonic neutral saline or acidic solution. Ninety min after beginning the experiments, animals sacrificed and the gastric mucosa collected to determine the pH, mucus secretion and to quantify the mRNA expression of EPs receptors by quantitative real-time PCR. Results: present results showed that a) NaHS increased the mucus secretion, mRNA expression of EP3 and EP4 receptors in response to distention-induced expression; b) The mRNA expression of EP1 receptors increased while EP4 mRNA receptors decreased in response to Mucosal acidification in NaHS-pretreated Rats; and c) NaHS increased pH of gastric contents both in response to distention-induced gastric acid secretion and Mucosal acidification. Conclusion: NaHS behaves in a different manner. It effectively only increased the pH of gastric contents to reinforce the gastric mucosa against a highly acidic solution but modulated both acid and mucus secretion when the Rate of acid increase in the stomach was slower.

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APA: Copy

MARD, SEYYED ALI, Mahini, Simin, DIANAT, MAHIN, & FARBOOD, YAGHOOB. (2017). Effect of sodium hydrosulfide on mRNA expression of prostaglandin E2 receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(2), 145-149. SID. https://sid.ir/paper/723757/en

Vancouver: Copy

MARD SEYYED ALI, Mahini Simin, DIANAT MAHIN, FARBOOD YAGHOOB. Effect of sodium hydrosulfide on mRNA expression of prostaglandin E2 receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(2):145-149. Available from: https://sid.ir/paper/723757/en

IEEE: Copy

SEYYED ALI MARD, Simin Mahini, MAHIN DIANAT, and YAGHOOB FARBOOD, “Effect of sodium hydrosulfide on mRNA expression of prostaglandin E2 receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 2, pp. 145–149, 2017, [Online]. Available: https://sid.ir/paper/723757/en

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