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Cites:

1

Information Journal Paper

Title

Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study

Pages

  446-450

Abstract

 In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic Quinoline compound (2-(4-Methoxyphenyl)benzo[h]Quinoline-4-carboxylic acid, QC), possessing structural elements of both Naproxen and Tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical-and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice. Results: QC displayed a dose dependent effect in both acute anti-nociceptive tests (writhing and hot plate). This compound at dose of 6. 562 mg/kg showed a high anti-nociceptive effect near equal to diclofenac 5 mg/kg. It also showed high anti-inflammatory effects (less than 6. 562 mg/kg) comparable to those of reference drugs diclofenac (5 mg/kg) and celecoxib (100 mg/kg). Docking study showed that this Quinoline derivative could inhibit COX-2 enzyme strongly. Conclusion: QC showed high anti-nociceptive and anti-inflammatory effects comparable to reference drugs and can exert its anti-nociceptive and anti-inflammatory activities through COX-2 inhibition.

Cites

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    • Cite

    APA: Copy

    HOSSEINZADEH, HOSSEIN, Mazaheri, Fatemeh, & GHODSI, RAZIEH. (2017). Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(4), 446-450. SID. https://sid.ir/paper/723767/en

    Vancouver: Copy

    HOSSEINZADEH HOSSEIN, Mazaheri Fatemeh, GHODSI RAZIEH. Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(4):446-450. Available from: https://sid.ir/paper/723767/en

    IEEE: Copy

    HOSSEIN HOSSEINZADEH, Fatemeh Mazaheri, and RAZIEH GHODSI, “Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 4, pp. 446–450, 2017, [Online]. Available: https://sid.ir/paper/723767/en

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