Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population‑ based study Isfahan, Iran

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KIANPOUR MARYAM; AMINORROAYA ASHRAF; AMINI MASSOUD; FEIZI AWAT; JANGHORBANI MOHSEN

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2018 | Volume:23 | Issue:11 Page(s): 0-0

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Title

Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population‑ based study Isfahan, Iran

Author(s)

Keywords

Cohort population‑based study

Iran

pregnancy outcomes

reference range

thyroid function

Abstract

Background: This paper presents the protocol and primary findings of pregnancy cohort population‑ based study in Isfahan, Iran. Materials and Methods: In this cohort, 418 pregnant and 438 nonpregnant women were enrolled. In the first phase, serum concentrations of thyroid‑ stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and urinary iodine concentration (UIC) were measured. Furthermore, the thyroid ultrasound was also performed. According to the results of thyroid function tests in the first phase, local reference range for TSH, FT4, and FT3 in pregnant and nonpregnant women are determined. The 2. 5th and 97. 5th percentiles are determined as limits of the reference ranges. In the second phase, all pregnant women underwent prenatal care visits in each trimester and they followed for 7 days after delivery and the pregnancy outcomes data are reported. Results: The mean ± standard deviation for TSH, FT4, FT3, and UIC in the first trimester of gestation was 1. 84 ± 1. 32 mIU/L, 1. 01 ± 0. 15 ng/dL, 4. 50 ± 0. 64 pmol/L, and 172. 0 ± 90. 29 μ g/L, respectively. In nonpregnant women, these values for TSH, FT4, FT3, and UIC were 2. 58 ± 1. 77 mIU/L, 1. 10 ± 0. 21 ng/dL, 4. 49 ± 0. 57 pmol/L, and 190. 0 ± 109. 6 μ g/L, respectively. Conclusions: The results of the present study could contribute to establish a local thyroid function tests reference ranges in the first trimester of pregnancy. It could possibly be effective on making a local reference value to prevent of thyroid disease misdiagnosis during pregnancy and adverse pregnancy outcomes.

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References

Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum

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APA: Copy

KIANPOUR, MARYAM, AMINORROAYA, ASHRAF, AMINI, MASSOUD, FEIZI, AWAT, & JANGHORBANI, MOHSEN. (2018). Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population‑ based study Isfahan, Iran. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(11), 0-0. SID. https://sid.ir/paper/724266/en

Vancouver: Copy

KIANPOUR MARYAM, AMINORROAYA ASHRAF, AMINI MASSOUD, FEIZI AWAT, JANGHORBANI MOHSEN. Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population‑ based study Isfahan, Iran. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(11):0-0. Available from: https://sid.ir/paper/724266/en

IEEE: Copy

MARYAM KIANPOUR, ASHRAF AMINORROAYA, MASSOUD AMINI, AWAT FEIZI, and MOHSEN JANGHORBANI, “Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population‑ based study Isfahan, Iran,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 11, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/724266/en

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