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Information Journal Paper

Title

Evaluation of the neuroprotective, anticonvulsant, and cognitionimprovement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway

Pages

  752-758

Abstract

 Objective(s): Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory. Herbal medicine is considered a complementary and alternative therapy in epilepsy. Apigenin is a safe flavone with antioxidant properties. However, there is little information about the beneficial effect of Apigenin on Cognition in epilepsy. Materials and Methods: For evaluating the Anticonvulsant effect of Apigenin in the kainite temporal epilepsy model, Apigenin was orally administered at 50 mg/kg for six days. Reference and working memory were examined via the Morris water maze and Y-maze task spontaneously. Results: Results showed that Apigenin had significant Anticonvulsant activity (P<0. 01) and restored the memory-deficit induced by kainic acid (P<0. 05). Furthermore, Apigenin significantly increased the number of living neurons in the hilus (P<0. 001). Immunohistochemical analysis showed that Apigenin reduced the release of Cytochrome c (P<0. 01), suggesting an inhibitory role in the intrinsic apoptotic pathway. Conclusion: These results suggest that Apigenin restores memory impairment via Anticonvulsant and neuroprotective activity.

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    Cite

    APA: Copy

    Hashemi, Paria, FAHANIK BABAEI, JAVAD, Vazifekhah, Somaye, & NIKBAKHT, FARNAZ. (2019). Evaluation of the neuroprotective, anticonvulsant, and cognitionimprovement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 752-758. SID. https://sid.ir/paper/725212/en

    Vancouver: Copy

    Hashemi Paria, FAHANIK BABAEI JAVAD, Vazifekhah Somaye, NIKBAKHT FARNAZ. Evaluation of the neuroprotective, anticonvulsant, and cognitionimprovement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):752-758. Available from: https://sid.ir/paper/725212/en

    IEEE: Copy

    Paria Hashemi, JAVAD FAHANIK BABAEI, Somaye Vazifekhah, and FARNAZ NIKBAKHT, “Evaluation of the neuroprotective, anticonvulsant, and cognitionimprovement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 752–758, 2019, [Online]. Available: https://sid.ir/paper/725212/en

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