Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats

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MOGHIMI MAHSA; PARVARDEH SIAVASH; MOINI ZANJANI TARANEH; Ghafghazi Shiva

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:9 Page(s): 960-969

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Title

Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats

Author(s)

MOGHIMI MAHSA | PARVARDEH SIAVASH | MOINI ZANJANI TARANEH | Ghafghazi Shiva | Issue Writer Certificate

Keywords

α-Terpineol

Cerebral ischemia

Long-term potentiation

Memory

Oxidative stress

Rats

Abstract

Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the Memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against Memory impairment following Cerebral ischemia in Rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar Rats. The Rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial Memory and in vivo extracellular recording of Long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P<0. 01). In addition, α-Terpineol increased the number of crossings over the platform location and decreased average proximity to the target in probe trial (P<0. 05). In electrophysiological recording, α-Terpineol (100 mg/kg) facilitated the induction of LTP in the hippocampus which was persistent over 2 hr. α-Terpineol (100 and 200 mg/kg) also significantly lowered hippocampal MDA levels in Rats subjected to Cerebral ischemia. Conclusion: These findings indicate that α-Terpineol improves Cerebral ischemia-related Memory impairment in Rats through the facilitation of LTP and suppression of lipid peroxidation in the hippocampus.

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Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex

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APA: Copy

MOGHIMI, MAHSA, PARVARDEH, SIAVASH, MOINI ZANJANI, TARANEH, & Ghafghazi, Shiva. (2016). Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(9), 960-969. SID. https://sid.ir/paper/725360/en

Vancouver: Copy

MOGHIMI MAHSA, PARVARDEH SIAVASH, MOINI ZANJANI TARANEH, Ghafghazi Shiva. Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(9):960-969. Available from: https://sid.ir/paper/725360/en

IEEE: Copy

MAHSA MOGHIMI, SIAVASH PARVARDEH, TARANEH MOINI ZANJANI, and Shiva Ghafghazi, “Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 9, pp. 960–969, 2016, [Online]. Available: https://sid.ir/paper/725360/en

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