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Information Journal Paper

Title

The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury

Pages

  970-976

Keywords

GDNF (glial cell linederived 
neurotrophic factor) 
Hemi-SCI (hemisection of spinal cord injury) 

Abstract

 Objective(s): Glial cell line-derived neurotrophic factor (GDNF) can effectively promote axonal regeneration， limit axonal retraction， and produce a statistically significant improvement in motor recovery after spinal cord injury (SCI). However, the role in primate animals with SCI is not fully cognized. Materials and Methods: 18 healthy juvenile rhesuses were divided randomly into six groups, observed during the periods of 24 hr, 7 days, 14 days, 1 month, 2 months, and 3 months after T11 hemisecting. The GDNF localization, changes in the injured region, and the remote associate cortex were detected by immunohistochemical staining. Results: Immunohistochemical staining showed that GDNF was located in the cytoplasm and the neurite of the neurons. Following SCI, the number of GDNF positive neurons in the ventral horn and the caudal part near the lesion area were apparently reduced at detected time points (P<0. 05). Moreover, the number in the rostral part of the ventral horn in 7 day, 14 day, and 1 month groups were fewer than those in the caudal part. Importantly, in the contralateral cortex motor area, the positive neurons decreased sharply after hemi-SCI, while gradually increased and went back to normal in 3 months after hemi-SCI. Conclusion: To sum up, GDNF disruption in neurons occurred after SCI especially in cortex motor area. Intrinsic GDNF in the spinal cord, plays an essential role in neuroplasticity. Thereafter extrinsic GDNF supplementing may be a useful strategy to promote recovery after SCI.

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    • Cite

    APA: Copy

    Qiu, De Lu, & Wang, Ting Hua. (2016). The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(9), 970-976. SID. https://sid.ir/paper/725683/en

    Vancouver: Copy

    Qiu De Lu, Wang Ting Hua. The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(9):970-976. Available from: https://sid.ir/paper/725683/en

    IEEE: Copy

    De Lu Qiu, and Ting Hua Wang, “The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 9, pp. 970–976, 2016, [Online]. Available: https://sid.ir/paper/725683/en

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