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Information Journal Paper

Title

Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats

Pages

  308-315

Keywords

((I/R)) 
Tanshinone IIA sodium-sulfonate (TSS) 

Abstract

 This study investigated the protective effect of tanshinone IIA sodium sulfonate (TSS) on ischemia-reperfusion ((I/R)) induced cardiac injury, and the underlying mechanism of action. Materials and Methods: Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by 24 hours' reperfusion. Half an hour before the left coronary artery ligation, rats were pretreated with TSS in three different dosages (15, 30, 70 mg/kg, IP). Twenty-four hours later, cardiac function was measured and the ratio of infarct size to area at risk (AAR) was calculated. Western blotting examined the expression of the inflammatory mediator high-mobility group box1 (HMGB-1), anti-apoptotic protein Bcl-2, pro-apoptotic mediators such as Bax and Caspase-3, markers of Autophagy such as ratio of LC3B/LC3A and Beclin-1 expression. Results: Our results showed that TSS dose-dependently improves cardiac function, accompanied with decrease of HMGB1 level, increase of LC3B/LC3A ratio and increase of Beclin-1 expression. TSS treatment down-regulates Bax and Caspase-3 expression, while up-regulating Bcl-2 levels. Conclusion: TSS ameliorates (I/R) induced myocardial injury and improves cardiac function via reducing inflammation and Apoptosis, while enhancing Autophagy.

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    APA: Copy

    Pan, Yun, Qian, Jin Xian, Lu, Shi Qi, Chen, Jing Wei, ZHAO, XIAODONG, JIANG, YAN, Wang, Lin Hui, & Zhang, Guo Xing. (2017). Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(3), 308-315. SID. https://sid.ir/paper/725764/en

    Vancouver: Copy

    Pan Yun, Qian Jin Xian, Lu Shi Qi, Chen Jing Wei, ZHAO XIAODONG, JIANG YAN, Wang Lin Hui, Zhang Guo Xing. Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(3):308-315. Available from: https://sid.ir/paper/725764/en

    IEEE: Copy

    Yun Pan, Jin Xian Qian, Shi Qi Lu, Jing Wei Chen, XIAODONG ZHAO, YAN JIANG, Lin Hui Wang, and Guo Xing Zhang, “Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 3, pp. 308–315, 2017, [Online]. Available: https://sid.ir/paper/725764/en

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