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Information Journal Paper

Title

Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma

Pages

  160-165

Abstract

 Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on Asthma using a murine model of Asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice were sensitized by OVA intraperitoneal injection on days 0 and 14, and received aerosolized OVA challenge for 30 min daily on days 21-23. T. IIA (10 mg/kg twice daily) intraperitoneal injection was performed on days 18-23. Results: Treatment of T. IIA reduced the levels of interleukin (IL)-4, IL-5, and IL-13 in bronchoalveolar lavage fluid (BALF) (P<0. 05 for all cases). The OVA-induced elevation of total white blood cells as well as differential white blood cells in BALF and blood were inhibited by T. IIA (P<0. 05 for all cases). Moreover, airway hyperresponsiveness was dampened in T. IIA-treated group (P<0. 05). T. IIA inhibited the activation of nuclear factor-κ B in Asthmatic mice (P<0. 05). The activity of nuclear factor erythroid-2-related factor 2 was enhanced in T. IIA-treated group (P<0. 05). T. IIA elevated the activities of heme oxygenase-1, glutathione peroxidase, and superoxide dismutase (P<0. 05 for all cases). Conclusion: T. IIA inhibits OVA-induced airway Inflammation and hyperresponsiveness. T. IIA is a potential therapeutic agent for Asthma.

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    APA: Copy

    Wang, Shi Biao, Guo, Xiao Feng, Weng, Bin, Tang, Su Ping, & Zhang, Hui Jie. (2019). Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(2), 160-165. SID. https://sid.ir/paper/726488/en

    Vancouver: Copy

    Wang Shi Biao, Guo Xiao Feng, Weng Bin, Tang Su Ping, Zhang Hui Jie. Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(2):160-165. Available from: https://sid.ir/paper/726488/en

    IEEE: Copy

    Shi Biao Wang, Xiao Feng Guo, Bin Weng, Su Ping Tang, and Hui Jie Zhang, “Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 2, pp. 160–165, 2019, [Online]. Available: https://sid.ir/paper/726488/en

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