Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemiareperfusion injury rats

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Ko Cheng Hang; Huang Chun-Ping; Lin Yi Wen; Hsieh Ching Liang

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:11 Page(s): 1174-1178

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Title

Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemiareperfusion injury rats

Author(s)

Ko Cheng Hang | Huang Chun-Ping | Lin Yi Wen | Hsieh Ching Liang | Issue Writer Certificate

Keywords

Apoptosis

Inflammation

Neurogenesis

Nicotinic acetylcholine-receptor

Paeoniflorin

Stroke

Abstract

Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-Inflammation, anti-Apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to investigate the neuroprotection mechanisms of PF in cerebral ischemia-reperfusion injury rats. Materials and Methods: We established an animal model of cerebral infarct by occlusion of the middle cerebral artery for 15 min, followed by reperfusion, and PF was administered 24 hr later (20 mg/kg, intraperitoneally for 6 days) after reperfusion Results: Treatment with PF reduced the neurological deficit score, improved motor function, decreased cell counts of nicotinic acetylcholine receptor (nAChR) α 4β 2 immunoreactive cells, and increased cell counts of nAChR α 7. Furthermore, PF administration suppressed neuronal Apoptosis and promoted Neurogenesis. Conclusion: PF rescued neurological deficit and underlying mechanisms were inhibition of neurological Apoptosis and Inflammation by nAChRs.

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APA: Copy

Ko, Cheng Hang, Huang, Chun-Ping, Lin, Yi Wen, & Hsieh, Ching Liang. (2018). Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemiareperfusion injury rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1174-1178. SID. https://sid.ir/paper/726430/en

Vancouver: Copy

Ko Cheng Hang, Huang Chun-Ping, Lin Yi Wen, Hsieh Ching Liang. Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemiareperfusion injury rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1174-1178. Available from: https://sid.ir/paper/726430/en

IEEE: Copy

Cheng Hang Ko, Chun-Ping Huang, Yi Wen Lin, and Ching Liang Hsieh, “Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemiareperfusion injury rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1174–1178, 2018, [Online]. Available: https://sid.ir/paper/726430/en

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