مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

225
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

178
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide

Pages

  201-208

Abstract

 Objective(s): Dependence and Tolerance to opioid analgesics are major problems limiting their clinical application. -Terpineol is a Monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate Dependence and Tolerance to Morphine. Since -Terpineol is one of the bioactive phytochemical constituent of these medicinal plants, the present study was conducted to investigate the effects of -Terpineol on Morphine-induced Dependence and Tolerance in mice. Materials and Methods: The mice were rendered dependent or tolerant to Morphine by a 3-day administration schedule. The hot-plate test and naloxone-induced withdrawal syndrome were used to evaluate Tolerance and Dependence on Morphine, respectively. To investigate a possible role for Nitric oxide (NO) in the protective effect of -Terpineol, the NO synthase inhibitor, L-N(G)-nitroarginine methyl ester (L-NAME) and NO precursor, L-arginine, were used. Results: Administration of -Terpineol (5, 10, and 20 mg/kg, IP) significantly decreased the number of jumps in Morphine dependent animals. Moreover, -Terpineol (20 and 40 mg/kg, IP) attenuated Tolerance to the analgesic effect of Morphine. The inhibitory effects of -Terpineol on Morphine-induced Dependence and Tolerance were enhanced by pretreatment with L-NAME (10 mg/kg, IP). However, L-arginine (300 mg/kg, IP) antagonized the protective effects of -Terpineol on Dependence and Tolerance to Morphine. Conclusion: These findings indicate that -Terpineol prevents the development of Dependence and Tolerance to Morphine probably through the influence on NO production.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    PARVARDEH, SIAVASH, MOGHIMI, MAHSA, Eslami, Pegah, & MASOUDI, ALIREZA. (2016). -Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(2), 201-208. SID. https://sid.ir/paper/726445/en

    Vancouver: Copy

    PARVARDEH SIAVASH, MOGHIMI MAHSA, Eslami Pegah, MASOUDI ALIREZA. -Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(2):201-208. Available from: https://sid.ir/paper/726445/en

    IEEE: Copy

    SIAVASH PARVARDEH, MAHSA MOGHIMI, Pegah Eslami, and ALIREZA MASOUDI, “-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 2, pp. 201–208, 2016, [Online]. Available: https://sid.ir/paper/726445/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button