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Information Journal Paper

Title

The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart

Pages

  731-737

Abstract

 Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving Heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-Rb1, adenine 9-β-D-arabinofuranoside (Ara A, specific AMPK inhibitor), and 5'-aminoimidazole-4-carboxamide riboside (Aicar, specific AMPK activator) were administered to rats with HF, singly and/or combinedly. Myocardial high-energy phosphate (such as phosphocreatine, ADP, and ATP), free L-Carnitine, Malonyl-CoA, and the activity of FAO-related enzymes in left ventricle from different groups were measured by using the corresponding molecular biological techniques. Results: Gs-Rb1 improved HF significantly, accompanied by a significant increase in phosphocreatine (PCr), ADP, ATP, PCr/ATP ratio, free carnitine, Malonyl-CoA, mRNA, activity of Carnitine palmitoyltransferase (Cpt), Medium-chain acyl-CoA dehydrogenase (MCAD) and Long-chain acyl-CoA synthetase (ACSL) and a significant decrease of the ADP/ATP ratio in the left ventricular myocardium. However, all those effects were almost abolished by Ara A and were not further improved by Aicar. Conclusion: Taken together, it suggests that Gs-Rb1 may modulate cardiac metabolic remodeling by improving myocardial fatty acid β-oxidation in failing heart. In addition, the effects of Gs-Rb1 may be mediated via activating AMPK.

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    APA: Copy

    Hou, Ai jie, Kong, Hong liang, Liu, Ning ning, Chen, Bo han, Dai, Sheng nan, & Huang, Hua ting. (2018). The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(7), 731-737. SID. https://sid.ir/paper/726506/en

    Vancouver: Copy

    Hou Ai jie, Kong Hong liang, Liu Ning ning, Chen Bo han, Dai Sheng nan, Huang Hua ting. The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(7):731-737. Available from: https://sid.ir/paper/726506/en

    IEEE: Copy

    Ai jie Hou, Hong liang Kong, Ning ning Liu, Bo han Chen, Sheng nan Dai, and Hua ting Huang, “The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 7, pp. 731–737, 2018, [Online]. Available: https://sid.ir/paper/726506/en

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