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Information Journal Paper

Title

Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice

Pages

  708-714

Abstract

 Objective(s): The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. Materials and Methods: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0. 5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0. 5, 1, and 2 mg/kg) with the same route were assessed in FST and Tail suspension test (TST). Anti-anxiety and motor activities were evaluated using elevated plus-maze (EPM) and open field tests, respectively. Determination of different constituents within the sample oil was via gas chromatography– mass spectrometry (GC– MS) analysis. Results: Repetitive administration of cinnamon essential oil (0. 5, 1, 2 mg/kg) during 14 days significantly decreased the time of immobility in both FST and TST as compared to the control group. Mice treated with oil at the dose of 2 mg/kg spent a longer time and had more entries into the open arms of EPM as compared with the vehicle-treated ones. According to GC-MS analysis, 46 chemical compounds were identified in the studied cinnamon essential oil with the main constituent being trans-cinnamaldehyde (87. 32%). Conclusion: Cinnamon essential oil might be used as an adjunctive therapy in improving symptoms of depressive and anxiety disorders. However, dose-response effects need further evaluation. Trans-cinnamaldehyde might be responsible for the beneficial effect observed.

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    APA: Copy

    Sohrabi, Reyhaneh, Pazgoohan, Nasim, REZAEI SERESHT, HASAN, & AMIN, BAHAREH. (2017). Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(6), 708-714. SID. https://sid.ir/paper/726651/en

    Vancouver: Copy

    Sohrabi Reyhaneh, Pazgoohan Nasim, REZAEI SERESHT HASAN, AMIN BAHAREH. Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(6):708-714. Available from: https://sid.ir/paper/726651/en

    IEEE: Copy

    Reyhaneh Sohrabi, Nasim Pazgoohan, HASAN REZAEI SERESHT, and BAHAREH AMIN, “Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 6, pp. 708–714, 2017, [Online]. Available: https://sid.ir/paper/726651/en

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