Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling

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LU MING; LUO YING; HUO PENGFEI; Dou Liping; Huang Shuwei

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:1 Page(s): 83-88

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Title

Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling

Author(s)

Keywords

Advanced

ERK1/2

Glycation end products

JNK

P38

Tanshinone IIA

Vascular Smooth Muscle

Abstract

Objective(s): Vascular Smooth Muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of Tanshinone IIA on the proliferation and migration of VSMCs induced by Advanced Glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of Tanshinone IIA by cell proliferation assay and cell migration assay. And we explored the underlying mechanism by Western blotting. Results: AGEs significantly induced the proliferation and migration of VSMCs, but treatment with Tanshinone IIA attenuated these effects. AGEs could increase the activity of the ERK1/2 and P38 pathways but not the JNK pathway. Treatment with Tanshinone IIA inhibited the AGEs-induced activation of the ERK1/2 pathway but not the P38 pathway. Conclusion: Tanshinone IIA inhibits AGEs-induced proliferation and migration of VSMCs by suppressing the ERK1/2 MAPK signaling pathway.

Cites

Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma

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APA: Copy

LU, MING, LUO, YING, HUO, PENGFEI, Dou, Liping, & Huang, Shuwei. (2018). Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(1), 83-88. SID. https://sid.ir/paper/726775/en

Vancouver: Copy

LU MING, LUO YING, HUO PENGFEI, Dou Liping, Huang Shuwei. Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(1):83-88. Available from: https://sid.ir/paper/726775/en

IEEE: Copy

MING LU, YING LUO, PENGFEI HUO, Liping Dou, and Shuwei Huang, “Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 1, pp. 83–88, 2018, [Online]. Available: https://sid.ir/paper/726775/en

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