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Information Journal Paper

Title

Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China

Pages

  610-616

Abstract

 Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) Polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China). Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01– 08 of 201 RA patients and 211 healthy individuals from Zhongda Hospital (China). The allele frequency distribution of HLA-Cw and genotypic differences between the two groups were analyzed. Results: The frequency of HLA-Cw0303 in patients with RA was significantly higher than that in controls, while the frequency of HLA-Cw04 was lower than that in controls (P<0. 05). The Gene frequency of HLA-Cw07 in anti-cyclic citrullinated peptide (anti-CCP)-negative patients was higher than that in controls (P=0. 044). The frequency of HLA-Cw04 was decreased in the short duration subgroup and increased in the long duration subgroup (P<0. 05). Compared to controls, the frequency of HLA-Cw0303 in patients with RA and morning stiffness was increased (P=0. 004), while the frequency of HLA-Cw04 was decreased ( 0. 005). Conclusion: These results suggest that HLA-Cw0303 is a susceptibility gene for RA in Chinese Han patients in the Jiangsu area of southern China. The HLA-Cw04 gene may be a protective factor against RA, while HLA-Cw07 might play a protective role in the production of anti-CCP in the long-term course in patients with RA.

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    APA: Copy

    Yang, Chuankun, Wang, Chunling, Shi, Yan, & LI, LI. (2019). Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 610-616. SID. https://sid.ir/paper/726779/en

    Vancouver: Copy

    Yang Chuankun, Wang Chunling, Shi Yan, LI LI. Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):610-616. Available from: https://sid.ir/paper/726779/en

    IEEE: Copy

    Chuankun Yang, Chunling Wang, Yan Shi, and LI LI, “Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 610–616, 2019, [Online]. Available: https://sid.ir/paper/726779/en

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