CELLULAR INJURY AND VARIOUS RECEPTOR EXPRESSION IN THE EPILEPTIC HUMAN AMYGDALA (ORAL PRESENTATION)

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JAFARIAN MARYAM; MODARRES MOUSAVI SAYED MOSTAFA; ALIPOUR FATEMEH; KHALEGHI GHADIRI MARYAM; GORJI ALI

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Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:3 (SUPPLEMENT 2) Page(s): 19-19

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Title

CELLULAR INJURY AND VARIOUS RECEPTOR EXPRESSION IN THE EPILEPTIC HUMAN AMYGDALA (ORAL PRESENTATION)

Author(s)

Keywords

HUMAN EPILEPTIC TISSUE

AMYGDALA

TEMPORAL LOBEEPILEPSY

EXCITATORY RECEPTORS

INHIBITORY RECEPTORS

Abstract

Mesial temporal lobe epilepsy (MTLE) is the most ordinary type of partial onset epilepsy. Despite several types of treatment, going therapies are insufficient about 20% to 30% of patients. For some, other therapeutic options are need. To achieve this goal, it is essential to develop more precisely the molecular and cellular mechanisms of the disease. This study was planned according to the role of excitatory and inhibitory roles of some important receptors in the amygdale complex as a major part of temporal lobe and effects of these changes on AMYGDALA damage and function. We evaluated AMYGDALA damage by tunnel staining correlate with alteration in GABAA (Ra1, Rb3, and Rg2), GABACRp2, GAD and GABAB (R1, and R2), also Glutamate receptors NMDA (NR2B, NR1, and mGluR1a) and AMPA (GluR1, GluR2) immonore activity to measure the expression and distribution of these receptors. The present data revealed an increased rate of Dark cells as a hallmark of cell damage as well as apoptotic cells as a marker for dell death, and decreased expression levels of several GABAergic receptor subunits and GAD65 in the AMYGDALA obtained during epilepsy surgery compared to autopsy specimens. Furthermore, the increased occurrence of apoptotic cells in the AMYGDALA was negatively correlated with the reduced expression of the studied GABAergic receptor subunits and GAD65. The present data indicate the importance of GABAergic neurotransmission in seizure-induced cell injury in the AMYGDALA and suggest several GABA receptor subunits as potential candidates for preventive and therapeutic management to control epilepsy and its comorbid disorders, such as anxiety.

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APA: Copy

JAFARIAN, MARYAM, MODARRES MOUSAVI, SAYED MOSTAFA, ALIPOUR, FATEMEH, KHALEGHI GHADIRI, MARYAM, & GORJI, ALI. (2018). CELLULAR INJURY AND VARIOUS RECEPTOR EXPRESSION IN THE EPILEPTIC HUMAN AMYGDALA (ORAL PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(3 (SUPPLEMENT 2)), 19-19. SID. https://sid.ir/paper/728329/en

Vancouver: Copy

JAFARIAN MARYAM, MODARRES MOUSAVI SAYED MOSTAFA, ALIPOUR FATEMEH, KHALEGHI GHADIRI MARYAM, GORJI ALI. CELLULAR INJURY AND VARIOUS RECEPTOR EXPRESSION IN THE EPILEPTIC HUMAN AMYGDALA (ORAL PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(3 (SUPPLEMENT 2)):19-19. Available from: https://sid.ir/paper/728329/en

IEEE: Copy

MARYAM JAFARIAN, SAYED MOSTAFA MODARRES MOUSAVI, FATEMEH ALIPOUR, MARYAM KHALEGHI GHADIRI, and ALI GORJI, “CELLULAR INJURY AND VARIOUS RECEPTOR EXPRESSION IN THE EPILEPTIC HUMAN AMYGDALA (ORAL PRESENTATION),” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 3 (SUPPLEMENT 2), pp. 19–19, 2018, [Online]. Available: https://sid.ir/paper/728329/en

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