EFFECT OF ALCOHOLIC EXTRACT OF SOUR ORANGE PEEL ON TOTAL ANTIOXIDANT, INSULIN LEVEL AND HYPERGLYCEMIA IN ALLOXANIZED RATS

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LAKZAEI M.; POURAMIR M.; MOGHADAMNIA A.A.; MIR H.

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Journal: Journal of Babol University of Medical Sciences Year:2012 | Volume:14 | Issue:1 (64) Page(s): 19-24

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Title

EFFECT OF ALCOHOLIC EXTRACT OF SOUR ORANGE PEEL ON TOTAL ANTIOXIDANT, INSULIN LEVEL AND HYPERGLYCEMIA IN ALLOXANIZED RATS

Author(s)

LAKZAEI M. | POURAMIR M. | MOGHADAMNIA A.A. | MIR H. | Issue Writer Certificate

Keywords

SOUR ORANGEQ2

ALLOXANQ2

INSULINQ2

HYPERGLYCEMIAQ2

ANTIOXIDANTQ2

Abstract

BACKGROUND AND OBJECTIVE: SOUR ORANGE is known as an herbal plant in traditional medicine. Previous studies indicate a protective effect of citrus fruits or juices against risk of some chronic diseases such as diabetes. The aim of this study was to investigate the ANTIOXIDANT and anti- hyperglycemic effects of alcoholic extract of SOUR ORANGE peel in rats with ALLOXAN induced HYPERGLYCEMIA.METHODS: In this experimental study, there were 120 Wistar rats weighing 150-200 gr that were divided into 6 groups (20 rats in each group) divided into two time groups (24 and 48 h). Ethanol extract of SOUR ORANGE peel was prepared. Animals were pretreated for 4 days in 2 different doses 100 and 300 mg/kg.100 mg/kg bw ALLOXAN injected intraperitoneally. After 24, 48 h blood sample collected and glucose (via glucose kit), serum ANTIOXIDANT levels (via FRAP) and serum INSULIN levels (via ELISA assay) were measured and the groups were compared.FINDINGS: Twenty four hours after ALLOXAN injection rats who received 300 mg/kg/day showed a significant increase in total ANTIOXIDANT content (p=0.000) and significant increase in glucose level after 48 hours (p=0.001). The administration of SOUR ORANGE peel extract (100 and 300 mg/kg/day) decreased serum INSULIN level in ALLOXAN-induced hyperglycemic rats at 24 and 48 hours after ALLOXAN injection (p<0.03).CONCLUSION: This study demonstrated that treatment with SOUR ORANGE peel extract not only brought a significant increase INSULIN concentration but also decreased the INSULIN level and also increased glucose concentration in ALLOXANized rats.

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APA: Copy

LAKZAEI, M., POURAMIR, M., MOGHADAMNIA, A.A., & MIR, H.. (2012). EFFECT OF ALCOHOLIC EXTRACT OF SOUR ORANGE PEEL ON TOTAL ANTIOXIDANT, INSULIN LEVEL AND HYPERGLYCEMIA IN ALLOXANIZED RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 14(1 (64)), 19-24. SID. https://sid.ir/paper/72856/en

Vancouver: Copy

LAKZAEI M., POURAMIR M., MOGHADAMNIA A.A., MIR H.. EFFECT OF ALCOHOLIC EXTRACT OF SOUR ORANGE PEEL ON TOTAL ANTIOXIDANT, INSULIN LEVEL AND HYPERGLYCEMIA IN ALLOXANIZED RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2012;14(1 (64)):19-24. Available from: https://sid.ir/paper/72856/en

IEEE: Copy

M. LAKZAEI, M. POURAMIR, A.A. MOGHADAMNIA, and H. MIR, “EFFECT OF ALCOHOLIC EXTRACT OF SOUR ORANGE PEEL ON TOTAL ANTIOXIDANT, INSULIN LEVEL AND HYPERGLYCEMIA IN ALLOXANIZED RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 14, no. 1 (64), pp. 19–24, 2012, [Online]. Available: https://sid.ir/paper/72856/en

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