HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE

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ASSADI ASSAD; TATI PARISA; SHARIFI RASUL; NOURAFCAN HASSAN; Mohebalipour Naser

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Journal: Iranian Journal of Diabetes and Metabolism Year:2017 | Volume:17 | Issue:1 Page(s): 1-12

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Title

HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE

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Keywords

DIABETESQ2

GREEN WHEAT LEAVESQ1

ALLOXANQ3

TOTAL ANTIOXIDANT CAPACITYQ1

OXIDATIVE STRESSQ1

Abstract

Background: DIABETES is one of the most common diseases of the body's endocrine system, Based on present forecasts of its prevalence will increase in human societies. DIABETES mellitus consists of 5 groups, its two major groups: type I DIABETES or insulin-dependent and type II DIABETES or non-insulin dependent DIABETES. The aim of this study was to evaluate the effect of alcoholic extract of GREEN WHEAT LEAVES on glucose, cholesterol, triglycerides, LDL, HDL and TOTAL ANTIOXIDANT CAPACITY of blood serum in ALLOXAN-induced diabetic mice.Methods: In this study, 40 male mice with an average weight of 25-20 grams in eight groups of five rats: The negative control, positive control (sham), Methformin (60mg/kg), green Wheat leaf extract (100, 200, 400, 800 and 1000mg/kg) were tested. Blood glucose was measured at baseline, then in the positive control group and the experimental groups by ALLOXAN (120mg/kg) DIABETES was induced by intraperitoneally. During the study, the positive control group and experimental groups received aforementioned compounds for 10 days via intraperitoneally and after 48 hours of each group blood samples were taken through the intraventricular anesthesia and glucose, cholesterol, triglycerides, LDL, HDL and TOTAL ANTIOXIDANT CAPACITY in serum were measured. Quantitative results achieved in this research by one-way ANOVA and Tukey post hoc test between the groups studied Considering the significance level of p<% 5 were analyzed.Results: The results showed that blood glucose changes in green Wheat leaf extract and metformin groups compared with the positive control group and negative control group was significant at the 5% level and In all under study groups blood glucose levels, Compared with the positive control group decreased and is close to the negative control group also in doses of 100, 200, 800 and 1000 mg/kg Reduced blood glucose is better than methformin group. Methformin and green Wheat leaf extract caused a significant increase at all doses studied in the TAC's Blood. Methformin and green Wheat leaf extract on the amounts of LDL, HDL and cholesterol in diabetic groups had no significant effect and did not have significant difference with other groups. There was no significant effect of different doses of green Wheat leaf extract on the blood triglycerides. However, metformin has a significant impact on triglyceride levels.Conclusion: The results of the effects of green Wheat leaf extract on glucose and serum antioxidant capacity It can be noted that these extracts in the treatment of DIABETES and reduce its complications can be considered as an option.

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APA: Copy

ASSADI, ASSAD, TATI, PARISA, SHARIFI, RASUL, NOURAFCAN, HASSAN, & Mohebalipour, Naser. (2017). HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 17(1 ), 1-12. SID. https://sid.ir/paper/54038/en

Vancouver: Copy

ASSADI ASSAD, TATI PARISA, SHARIFI RASUL, NOURAFCAN HASSAN, Mohebalipour Naser. HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2017;17(1 ):1-12. Available from: https://sid.ir/paper/54038/en

IEEE: Copy

ASSAD ASSADI, PARISA TATI, RASUL SHARIFI, HASSAN NOURAFCAN, and Naser Mohebalipour, “HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 17, no. 1 , pp. 1–12, 2017, [Online]. Available: https://sid.ir/paper/54038/en

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