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Information Journal Paper

Title

Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model

Pages

  789-796

Abstract

 Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of Silibinin, a potent radical scavenger on liver I/RI. Materials and Methods: Thirty-two rats were divided into 4 groups. Group I: VEHICLE, the rats underwent laparotomy and received DMSO, group II: SILI, laparotomy was done and Silibinin was administered. Group III: I/R, the rats received DMSO and were subjected to a liver I/R procedure and group IV: I/R+SILI, the animals underwent the I/R procedure and received Silibinin. After 1 hr of ischemia followed by 3 hr reperfusion, blood was collected to evaluate the serum marker of liver injuries. Hepatic tissue was harvested to investigate glycogen content, histological changes, and vasoregulatory gene expression. Results: Results showed that serum AST, ALT, LDH, GGT, ALP, and hyaluronic acid (HA) increased significantly in I/R group compared with the VEHICLE group. Silibinin reduced this elevation except for GGT. Silibinin inhibited hepatocyte vacuolization and degeneration, endothelium damages, sinusoidal congestion and inflammation, and glycogen depletion during I/R. ET-1 mRNA was overproduced in the I/R group compared with the VEHICLE group which was decreased by Silibinin. KLF2 and eNOS expression was reduced during I/R compared with the VEHICLE group. Silibinin elevated KLF2 expression but had no meaningful effect on eNOS expression. Conclusion: Silibinin protected the liver from I/RI. Silibinin could improve liver circulation by preventing sinusoidal congestion, inflammation, and perhaps modification of the vasoregulatory gene expression.

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References

Cite

APA: Copy

AKBARI KORDKHEYLI, VAHID, AZIZI, SOHEIL, & KHONAKDAR TARSI, ABBAS. (2019). Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 789-796. SID. https://sid.ir/paper/730449/en

Vancouver: Copy

AKBARI KORDKHEYLI VAHID, AZIZI SOHEIL, KHONAKDAR TARSI ABBAS. Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):789-796. Available from: https://sid.ir/paper/730449/en

IEEE: Copy

VAHID AKBARI KORDKHEYLI, SOHEIL AZIZI, and ABBAS KHONAKDAR TARSI, “Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 789–796, 2019, [Online]. Available: https://sid.ir/paper/730449/en

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