مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23

Pages

  1331-1336

Abstract

 Objective(s): Vascular calcification is one the major characteristics in patients with various types of Chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. Materials and Methods: In the current study, we built a vascular calcification rat model using vitamin D3 plus nicotine and analyzed miRNA expression profile by miRNA chip assay. Potential target of one selected miRNA with sharpest variation in expression were predicted by both PicTar and TargetScan. The impact of the selected miRNA on the expression of the potential target on both mRNA and protein levels were measured by RT-PCR and Western blot, respectively. Results: Our results identified 16 dysregulated miRNAs, among which miR-297a showed the sharpest variation. Further analysis focusing on miR-297a revealed that Fibroblast growth factor 23 (FGF23) was a potential target of miR297a. Measurement of FGF23 and its regulator Klotho on both mRNA and protein levels demonstrated that FGF23 was significantly increased while Klotho was decreased in rats with vascular calcification. Conclusion: Our results indicated that FGF23 was target of miR-297a and decreased miR-297a in vascular calcification lead to the increase of FGF23, which together with Klotho might enhance vascular calcification. The findings of this study could provide valuable information for the understanding of mechanisms underlying miR-dependent vascular calcification as well as potential treatment target for the disease.

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    APA: Copy

    Zheng, Shouhua, Zhang, Shuijun, Song, Yan, Guo, Wenzhi, Zhai, Wenlong, Qiu, Xinguang, & Li, Jianhua. (2016). MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(12), 1331-1336. SID. https://sid.ir/paper/731174/en

    Vancouver: Copy

    Zheng Shouhua, Zhang Shuijun, Song Yan, Guo Wenzhi, Zhai Wenlong, Qiu Xinguang, Li Jianhua. MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(12):1331-1336. Available from: https://sid.ir/paper/731174/en

    IEEE: Copy

    Shouhua Zheng, Shuijun Zhang, Yan Song, Wenzhi Guo, Wenlong Zhai, Xinguang Qiu, and Jianhua Li, “MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 12, pp. 1331–1336, 2016, [Online]. Available: https://sid.ir/paper/731174/en

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