مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms

Pages

  1368-1395

Abstract

 Objective(s): Carthamus tinctorius L. (CT) or safflower is widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia– reperfusion (I/R) brain Injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0. 2-0. 6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period. The cerebral infarction area, neurological deficit scores, Free radicals (lucigenin chemiluminescence counts) and pro-inflammatory cytokines expression were measured. Results: Pretreatment and treatment with CTE significantly reduced the cerebral infarction area and neurological deficits. CTE (0. 4 g/kg) also reduced blood levels of Free radicals and expression of tumor necrosis factor-α and interleukin-1β in the cerebral infarction area. Conclusion: The reduction in I/R cerebral infarction caused by CTE is possibly associated with its antioxidation and anti-inflammatory properties.

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    APA: Copy

    Fu, Pin Kuei, Pan, Tai Long, Yang, Chi Yu, JENG, KEE CHING, Tang, Nou Ying, & Hsieh, Ching Liang. (2016). Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(12), 1368-1395. SID. https://sid.ir/paper/731175/en

    Vancouver: Copy

    Fu Pin Kuei, Pan Tai Long, Yang Chi Yu, JENG KEE CHING, Tang Nou Ying, Hsieh Ching Liang. Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(12):1368-1395. Available from: https://sid.ir/paper/731175/en

    IEEE: Copy

    Pin Kuei Fu, Tai Long Pan, Chi Yu Yang, KEE CHING JENG, Nou Ying Tang, and Ching Liang Hsieh, “Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 12, pp. 1368–1395, 2016, [Online]. Available: https://sid.ir/paper/731175/en

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