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Information Journal Paper

Title

The effect of salusin-β on expression of pro-and anti-inflammatory cytokines in human umbilical vein endothelial cells (HUVECs)

Pages

  1-10

Abstract

 BACKGROUND: Atherosclerosis is one of the predominant causes of cardiovascular disease (CVD). Several studies indicated the significant pathophysiological role of salusin-β in Atherosclerosis. Cytokines are involved in all stages of Atherosclerosis. Therefore, we aimed to assess the effect of salusin-β on interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18) (as inflammatory Cytokines) and interleukin 1Ra (IL-1Ra) (as anti-inflammatory Cytokines) levels in human umbilical vein Endothelial Cells (HUVECs). METHODS: The HUVECs were cultured in HUVEC completed medium and treated with different doses of salusin-β for 6 and 12 hours. For the investigation of nuclear factor ƙ β (NF-ƙ β ) signaling pathway involvement, cells were treated in the presence or absence of Bay 11-7082 (as NF-ƙ β inhibitor). The mRNA expression and protein level of Cytokines were measured by a realtime polymerase chain reaction (PCR) system and enzyme-linked immunosorbent assay (ELISA) method, respectively. RESULTS: Salusin-β increased mRNA expression and protein level of IL-6, IL-8 and IL-18. This protein decreased mRNA and protein level of IL-1Ra in HUVECs. NF-ƙ β signaling pathway was involved in the up-regulatory effect of salusin-β on mRNA expression of pro-inflammatory Cytokines. The down-regulatory effect of salusin-β on IL-1Ra expression could not be influenced by Bay 11-7082 pre-treatment. CONCLUSION: It seems that salusin-β may participate in a cascade pathway in vascular Inflammation. Our findings suggested that salusin-β has potential use as a therapeutic target for Atherosclerosis.

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    APA: Copy

    ESFAHANI, MARYAM, Saidijam, Masoud, NAJAFI, REZVAN, GOODARZI, MOHAMMAD TAGHI, & MOVAHEDIAN, AHMAD. (2018). The effect of salusin-β on expression of pro-and anti-inflammatory cytokines in human umbilical vein endothelial cells (HUVECs). ARYA ATHEROSCLEROSIS, 14(1), 1-10. SID. https://sid.ir/paper/731422/en

    Vancouver: Copy

    ESFAHANI MARYAM, Saidijam Masoud, NAJAFI REZVAN, GOODARZI MOHAMMAD TAGHI, MOVAHEDIAN AHMAD. The effect of salusin-β on expression of pro-and anti-inflammatory cytokines in human umbilical vein endothelial cells (HUVECs). ARYA ATHEROSCLEROSIS[Internet]. 2018;14(1):1-10. Available from: https://sid.ir/paper/731422/en

    IEEE: Copy

    MARYAM ESFAHANI, Masoud Saidijam, REZVAN NAJAFI, MOHAMMAD TAGHI GOODARZI, and AHMAD MOVAHEDIAN, “The effect of salusin-β on expression of pro-and anti-inflammatory cytokines in human umbilical vein endothelial cells (HUVECs),” ARYA ATHEROSCLEROSIS, vol. 14, no. 1, pp. 1–10, 2018, [Online]. Available: https://sid.ir/paper/731422/en

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