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Information Journal Paper

Title

6-Formylindolo[3, 2-b]carbazole (FICZ) Enhances The Expression of Tumor Suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p in MCF-7 Cells

Pages

  115-120

Abstract

 Objective: microRNAs (miRNAs) play bifunctional roles in the initiation and progression of cancer, and recent evidence has confirmed that unusual expression of miRNAs is required for the progress of breast cancer. The regulatory role of Aryl Hydrocarbon Receptor (AhR) and its endogenous ligand, 6-formylindolo[3, 2-b]carbazole (FICZ) on the expression of tumor suppressor miRNAs, miR-22, miR-515-5p and miR-124-3p, as well as their association with the Estrogen Receptor Alpha (ERα ) were the aims of this study. Materials and Methods: In this experimental study, the expression levels of miR-22, miR-515-5p, miR-124-3p and miR-382-5p in MCF-7 cells were determined using the quantificational real time polymerase chain reaction (qRT-PCR) assay. Results: Our results revealed that miR-22, miR-515-5p, and miR-124-3p expressions were significantly increased in cells transfected with ERα siRNA. Our data also showed that miR-22, miR 515-5p, and miR-124-3p expression levels were significantly increased following FICZ treatment. Here, we found that AhR/ERα cross-talk plays a critical role in the expression of miR-22, miR-515-5p and miR-124-3p in MCF-7 cells. Conclusion: Overall, our data demonstrated that FICZ, as an AhR agonist could induce the expression of tumor suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p; thus, FICZ might be regarded as a potential therapeutic agent for breast cancer treatment.

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    Cite

    APA: Copy

    MOBINI, KEIVAN, Banakar, Elham, TAMADDON, GHOLAMHOSSEIN, & MOHAMMADI BARDBORI, AFSHIN. (2020). 6-Formylindolo[3, 2-b]carbazole (FICZ) Enhances The Expression of Tumor Suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p in MCF-7 Cells. CELL JOURNAL (YAKHTEH), 22(1), 115-120. SID. https://sid.ir/paper/731652/en

    Vancouver: Copy

    MOBINI KEIVAN, Banakar Elham, TAMADDON GHOLAMHOSSEIN, MOHAMMADI BARDBORI AFSHIN. 6-Formylindolo[3, 2-b]carbazole (FICZ) Enhances The Expression of Tumor Suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p in MCF-7 Cells. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(1):115-120. Available from: https://sid.ir/paper/731652/en

    IEEE: Copy

    KEIVAN MOBINI, Elham Banakar, GHOLAMHOSSEIN TAMADDON, and AFSHIN MOHAMMADI BARDBORI, “6-Formylindolo[3, 2-b]carbazole (FICZ) Enhances The Expression of Tumor Suppressor miRNAs, miR-22, miR-515-5p, and miR-124-3p in MCF-7 Cells,” CELL JOURNAL (YAKHTEH), vol. 22, no. 1, pp. 115–120, 2020, [Online]. Available: https://sid.ir/paper/731652/en

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