A COMPARISON OF THE THERAPEUTIC EFFECTS OF METFORMIN, PIOGLITAZONE AND VITAMIN E IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER

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SHAHEBRAHIMI K.; ZULNOORIAN SH.; ALMASI A.; SHARIFI A.; KESHAVARZ A.A.; FARSHCHIAN N.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2017 | Volume:19 | Issue:9 Page(s): 32-38

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Title

A COMPARISON OF THE THERAPEUTIC EFFECTS OF METFORMIN, PIOGLITAZONE AND VITAMIN E IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER

Author(s)

Keywords

NON-ALCOHOLIC FATTY LIVER DISEASEQ1

METABOLIC SYNDROMEQ2

METFORMINQ2

PIOGLITAZONEQ2

VITAMIN EQ2

Abstract

BACKGROUND AND OBJECTIVE: NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) is specified by changes in fat in the liver, with or without inflammation. The disease is the hepatic manifestation of METABOLIC SYNDROME. Since a different medicinal treatment has been introduced, this study was conducted to compare the therapeutic effects of METFORMIN, PIOGLITAZONE and VITAMIN E in treatment of these patients.METHODS: In this single-blind randomized clinical trial, 93 patients with the diagnosis of NAFLD who referred to Imam Reza Hospital in Kermanshah were randomly divided into three groups (n = 31). Then, the first group received two gr/day METFORMIN, the second group received 30 mg/day PIOGLITAZONE and the third group received 800 IU/day VITAMIN E for 12 weeks. LFTs, BMI, HOMA-IR, FBS, and serum insulin levels were measured before and after the treatment course (IRCT: 2016010411991N3).FINDINGS: There was no significant difference between the groups in terms of distribution of sex, mean age, LFT and HOMA-IR before treatment. The mean difference in severity of NAFLD before or after the treatment was METFORMIN (1.06 ± 0.63), PIOGLITAZONE (1.195±0.75) and VITAMIN E (0.77±0.62), which was statistically significant (p<0.05). In addition, serum insulin levels (p<0.01) and HOMA-IR (p<0.05) were significant between the groups; PIOGLITAZONE showed highest effect on reducing the severity of NAFLD, serum insulin levels, and HOMA-IR. METFORMIN and VITAMIN E were next in line, respectively.CONCLUSION: Based on the results of this study, PIOGLITAZONE is more effective than METFORMIN and VITAMIN E both in reducing the severity of NAFLD and in lowering LFT and serum insulin levels.

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APA: Copy

SHAHEBRAHIMI, K., ZULNOORIAN, SH., ALMASI, A., SHARIFI, A., KESHAVARZ, A.A., & FARSHCHIAN, N.. (2017). A COMPARISON OF THE THERAPEUTIC EFFECTS OF METFORMIN, PIOGLITAZONE AND VITAMIN E IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 19(9 ), 32-38. SID. https://sid.ir/paper/73182/en

Vancouver: Copy

SHAHEBRAHIMI K., ZULNOORIAN SH., ALMASI A., SHARIFI A., KESHAVARZ A.A., FARSHCHIAN N.. A COMPARISON OF THE THERAPEUTIC EFFECTS OF METFORMIN, PIOGLITAZONE AND VITAMIN E IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2017;19(9 ):32-38. Available from: https://sid.ir/paper/73182/en

IEEE: Copy

K. SHAHEBRAHIMI, SH. ZULNOORIAN, A. ALMASI, A. SHARIFI, A.A. KESHAVARZ, and N. FARSHCHIAN, “A COMPARISON OF THE THERAPEUTIC EFFECTS OF METFORMIN, PIOGLITAZONE AND VITAMIN E IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 19, no. 9 , pp. 32–38, 2017, [Online]. Available: https://sid.ir/paper/73182/en

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