PALMITIC ACID-INDUCED TOXICITY REDUCTION DUE TO PRODUCTION OF TRIACYLGLYCEROL IN CARDIAC MUSCLE CELLS BY LINOLEIC ACID

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ZADEH HASHEM E.; PANAHANDEH F.; KOOHI M.K.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2016 | Volume:18 | Issue:7 Page(s): 34-40

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Title

PALMITIC ACID-INDUCED TOXICITY REDUCTION DUE TO PRODUCTION OF TRIACYLGLYCEROL IN CARDIAC MUSCLE CELLS BY LINOLEIC ACID

Author(s)

ZADEH HASHEM E. | PANAHANDEH F. | KOOHI M.K. | Issue Writer Certificate

Keywords

LINOLEIC ACIDQ1

LIPOTOXICITYQ1

PALMITIC ACIDQ1

RAT CARDIAC MUSCLEQ1

TRIACYLGLYCEROLQ2

DIACYLGLYCEROLQ1

Abstract

BACKGROUND AND OBJECTIVE: LIPOTOXICITY-induced cardiovascular diseases are increasing significantly in human populations. The effect of LINOLEIC ACID in reducing LIPOTOXICITY of cardiac muscle cells was investigated in this study. METHODS: In this empirical study, ventricular muscle cells from the hearts of five adult rats were cultured in 24-well plates. They were randomly treated in four groups including one control group (0.5 mM bovine serum albumin (BSA)) and three treatment groups treated with PALMITIC ACID (0.5 mM), LINOLEIC ACID (0.25 mM) and a combination of LINOLEIC ACID and PALMITIC ACID (0.25 mM+0.5 mM). Wells in each row of plates were dedicated to one group. Level of cellular TRIACYLGLYCEROL, cellular DIACYLGLYCEROL, DNA Fragmentation and survival rate was evaluated 24 and 48 hours after culturing. Each two wells belonging to each group were used to evaluate every factor and all the steps were repeated three times. FINDINGS: Compared with PALMITIC ACID treatment alone, adding LINOLEIC ACID to PALMITIC ACID decreased the level of DNA Fragmentation by 4.65% and 6.15% (p<0.001) and decreased cellular DIACYLGLYCEROL content by 0.36% and 4.88% (p>0.05). It also increased the level of cellular TRIACYLGLYCEROL by 40% and 44% (p<0.03) and increased cellular survival by 6.25% and 10.52% (p<0.01), respectively 24 and 48 hours after cultivation.CONCLUSION: Results of the study revealed that LINOLEIC ACID reduces the PALMITIC ACID-induced toxicity by producing TRIACYLGLYCEROL.

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APA: Copy

ZADEH HASHEM, E., PANAHANDEH, F., & KOOHI, M.K.. (2016). PALMITIC ACID-INDUCED TOXICITY REDUCTION DUE TO PRODUCTION OF TRIACYLGLYCEROL IN CARDIAC MUSCLE CELLS BY LINOLEIC ACID. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 18(7), 34-40. SID. https://sid.ir/paper/73203/en

Vancouver: Copy

ZADEH HASHEM E., PANAHANDEH F., KOOHI M.K.. PALMITIC ACID-INDUCED TOXICITY REDUCTION DUE TO PRODUCTION OF TRIACYLGLYCEROL IN CARDIAC MUSCLE CELLS BY LINOLEIC ACID. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2016;18(7):34-40. Available from: https://sid.ir/paper/73203/en

IEEE: Copy

E. ZADEH HASHEM, F. PANAHANDEH, and M.K. KOOHI, “PALMITIC ACID-INDUCED TOXICITY REDUCTION DUE TO PRODUCTION OF TRIACYLGLYCEROL IN CARDIAC MUSCLE CELLS BY LINOLEIC ACID,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 18, no. 7, pp. 34–40, 2016, [Online]. Available: https://sid.ir/paper/73203/en

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