The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Afzaljavan Fahimeh; Chaeichi Tehrani Negin; Rivandi Mahdi; Zarif Ghasemian Said; Vahednia Elham; Khayami Reza; Abavisani Mohammad; PASDAR ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2020 | Volume:22 | Issue:2 Page(s): 185-192

Download Full-Text

View:

268

Download:

180

Cites:

Information Journal Paper

Title

The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population

Author(s)

Keywords

Breast Cancer

Genetic Variation

Polymorphism

TP53

Abstract

Objective: Mutations of TP53 as a tumor suppressor gene are frequently observed in different types of cancer. A codon 72 Polymorphism located on exon 4 with two alleles encoding either Proline (CCC) or Arginine (CGC) has been indicated as a common variation in association with cancers. Controversial results have been reported regarding the association of allelic Polymorphism of codon 72 of TP53 gene and Breast Cancer risk in Iranian patients. Therefore, a case-control study was designed. A meta-analysis was also carried out to provide evidence of association between this variation and Breast Cancer in Iran, based on all available published data. Materials and Methods: In this case-control study, blood sample of 622 participants, including 308 Breast Cancer cases and 314 controls were collected. Genotyping for rs1042522 was conducted by Allele Specific polymerase chain reaction (AS-PCR). In order to set a meta-analysis study, PubMed, Scopus and ISI Web of Knowledge and Persian databases were searched to explore relevant studies, published up to September 2018, containing information on TP53 Polymorphism and the risk of Breast Cancer in Iran. Statistical analysis was performed using SPSS 16. 0 and MetaGenyo. Results: All retrieved available data as well as the results of our current study were consisted of 1965 Breast Cancer cases and 1999 healthy controls. No significant difference was observed in allele frequencies between groups (P=0. 90) in our study. The cumulative results did not also show any association between rs1042522 and Breast Cancer risk on the dominant (P=0. 61) and recessive (P=0. 89) models. Conclusion: These findings cannot support contribution of rs1042522 Polymorphism to Breast Cancer risk in an Iranian population. Future larger studies may help confirm this finding with a greater power.

Cites

No record.

References

Cite

APA: Copy

Afzaljavan, Fahimeh, Chaeichi Tehrani, Negin, Rivandi, Mahdi, Zarif Ghasemian, Said, Vahednia, Elham, Khayami, Reza, Abavisani, Mohammad, & PASDAR, ALIREZA. (2020). The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population. CELL JOURNAL (YAKHTEH), 22(2), 185-192. SID. https://sid.ir/paper/732173/en

Vancouver: Copy

Afzaljavan Fahimeh, Chaeichi Tehrani Negin, Rivandi Mahdi, Zarif Ghasemian Said, Vahednia Elham, Khayami Reza, Abavisani Mohammad, PASDAR ALIREZA. The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(2):185-192. Available from: https://sid.ir/paper/732173/en

IEEE: Copy

Fahimeh Afzaljavan, Negin Chaeichi Tehrani, Mahdi Rivandi, Said Zarif Ghasemian, Elham Vahednia, Reza Khayami, Mohammad Abavisani, and ALIREZA PASDAR, “The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population,” CELL JOURNAL (YAKHTEH), vol. 22, no. 2, pp. 185–192, 2020, [Online]. Available: https://sid.ir/paper/732173/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops