Anti-Platelet Therapy and the Risk of Upper Gastrointestinal Bleeding

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SADEGHI ANAHITA; BIGLARI MOHAMMAD; Fayaz Farhad; ALI ASGARI ALI

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Journal Paper

Paper Information

Journal: GOVARESH JOURNAL Year:2018 | Volume:23 | Issue:1 Page(s): 53-57

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Information Journal Paper

Title

Anti-Platelet Therapy and the Risk of Upper Gastrointestinal Bleeding

Author(s)

SADEGHI ANAHITA | BIGLARI MOHAMMAD | Fayaz Farhad | ALI ASGARI ALI | Issue Writer Certificate

Keywords

Antiplatelet therapy

Gastrointestinal bleeding

Endoscopy

Abstract

Background: We aimed to determine the effects of anti-platelet drugs use on adverse outcomes in patients with non-variceal upper Gastrointestinal bleeding (UGIB). Materials and Methods: A historical cohort study was performed on patients with non-variceal UGIB admitted to a tertiary care hospital. Clinical outcomes were compared among users of aspirin and patients who did not receive aspirin. Adverse outcome variables consisted of re-bleeding, need for surgery, and death Results: Out of 271 patients (77. 5% men, mean age 59. 5 ± 19. 0 years) with non-variceal UGIB, 157 (57. 9%) did not receive any antiplatelet drugs, 87 (32. 1%) received only aspirin, and 27 (10. 0%) received dual anti-platelet therapy. The frequency of adverse outcomes was significantly higher in patients who bled while not receiving anti-platelets (31. 2% no anti-platelets, 12. 6% single anti-platelet agent, and 14. 8% on dual anti-platelets, p = 0. 002). A significant difference in the duration of admission was not found between the three groups (5. 5 ± 4. 3 in patients with no anti-platelet drugs, 5. 6 ± 4. 6 in patients received single anti-platelet agent, and 5. 0 ± 4. 3 in patients received dual anti-platelets, p = 0. 84). Conclusion: Patients with non-variceal UGIB while taking anti-platelet drugs had a lower rate of adverse outcomes compared with non-users of anti-platelets.

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References

Oxford Vascular Study. Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study

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APA: Copy

SADEGHI, ANAHITA, BIGLARI, MOHAMMAD, Fayaz, Farhad, & ALI ASGARI, ALI. (2018). Anti-Platelet Therapy and the Risk of Upper Gastrointestinal Bleeding. GOVARESH JOURNAL, 23(1 ), 53-57. SID. https://sid.ir/paper/733294/en

Vancouver: Copy

SADEGHI ANAHITA, BIGLARI MOHAMMAD, Fayaz Farhad, ALI ASGARI ALI. Anti-Platelet Therapy and the Risk of Upper Gastrointestinal Bleeding. GOVARESH JOURNAL[Internet]. 2018;23(1 ):53-57. Available from: https://sid.ir/paper/733294/en

IEEE: Copy

ANAHITA SADEGHI, MOHAMMAD BIGLARI, Farhad Fayaz, and ALI ALI ASGARI, “Anti-Platelet Therapy and the Risk of Upper Gastrointestinal Bleeding,” GOVARESH JOURNAL, vol. 23, no. 1 , pp. 53–57, 2018, [Online]. Available: https://sid.ir/paper/733294/en

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