The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype

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Neyshaburinezhad Navid; HASHEMI MARYAM; RAMEZANI MOHAMMAD; Arabzadeh Sepideh; BEHRAVAN JAVAD; KALALINIA FATEMEH

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:11 Page(s): 1192-1197

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Title

The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype

Author(s)

Keywords

A2780

A2780-RCIS

Crocetin

MRP

Ovarian cancer cell line

Abstract

Objective(s): Crocetin, one of the main substances of saffron extract, has anti-cancer effects. Drug resistance proteins (e. g. MRP1 and MRP2) are important reasons for the failure of cancer therapy. We intended to investigate the efficacy of Crocetin on MRP1 and MRP2 activity in human ovarian cisplatinresistant carcinoma cell line (A2780-RCIS). Materials and Methods: The cytotoxic effect of Crocetin was evaluated by the MTT assay. The efficacy of Crocetin on MRP1 and MRP2 expression at mRNA level was studied by real-time RT-PCR. The effect of Crocetin on the activity of MRP transporters was determined by drug efflux assay. Results: Crocetin decreased cell proliferation in the A2780 (IC50: 183± 7 μ M) and A2780-RCIS (IC50: 316± 9 μ M). Crocetin decreased the expression level of MRP1 (22± 2 %) and MRP2 (48± 8 %) in A2780-RCIS and inhibited MRP pumps function directly in A2780 (44± 1 %) and A2780-RCIS (88± 10 %) and indirectly in A2780 (32± 2 %) and A2780-RCIS (48± 15 %) respectively. Conclusion: Our findings showed that Crocetin could quench drug resistance through modulation of MRP transporters in the drug resistant human ovarian cancer cells.

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References

THE EFFECT OF THE CROCUS SATIVUS L. CAROTENOID, CROCIN, ON THE POLYMERIZATION OF MICROTUBULES, IN VITRO

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APA: Copy

Neyshaburinezhad, Navid, HASHEMI, MARYAM, RAMEZANI, MOHAMMAD, Arabzadeh, Sepideh, BEHRAVAN, JAVAD, & KALALINIA, FATEMEH. (2018). The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1192-1197. SID. https://sid.ir/paper/734148/en

Vancouver: Copy

Neyshaburinezhad Navid, HASHEMI MARYAM, RAMEZANI MOHAMMAD, Arabzadeh Sepideh, BEHRAVAN JAVAD, KALALINIA FATEMEH. The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1192-1197. Available from: https://sid.ir/paper/734148/en

IEEE: Copy

Navid Neyshaburinezhad, MARYAM HASHEMI, MOHAMMAD RAMEZANI, Sepideh Arabzadeh, JAVAD BEHRAVAN, and FATEMEH KALALINIA, “The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1192–1197, 2018, [Online]. Available: https://sid.ir/paper/734148/en

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