Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules

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KAZEMI ARABABADI MOHAMMAD; ASADIKARAM GHOLAMREZA

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:2 Page(s): 215-220

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Title

Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules

Author(s)

KAZEMI ARABABADI MOHAMMAD | ASADIKARAM GHOLAMREZA | Issue Writer Certificate

Keywords

Apoptosis

Jurkat cells

PCR array

Abstract

Objective(s): The aim of this study was to determine the important molecules involved in Apoptosis induction by opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with 2. 86×10-5 g/ml concentration of opium and Apoptosis as well as expression levels of related molecules were measured. Results: Our results demonstrated that 50. 3± 0. 2 percent of opium treated Jurkat cells were revealed apoptotic features. The levels of mRNA of several pro-apoptotic and anti-apoptotic molecules were increased and decreased, respectively, in the opium treated cells. The results also demonstrated that expression levels of BCL2, DFFA and NOL3 as anti-apoptotic molecules were increased in the opium treated cells. Conclusion: It seems that opium induces Apoptosis in Jurkat cells via both intrinsic and extrinsic pathways. Although opium induces Apoptosis in the cells but increased expression of some anti-apoptotic molecules may be a normal resistance of the cell for death.

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APA: Copy

KAZEMI ARABABADI, MOHAMMAD, & ASADIKARAM, GHOLAMREZA. (2016). Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(2), 215-220. SID. https://sid.ir/paper/734161/en

Vancouver: Copy

KAZEMI ARABABADI MOHAMMAD, ASADIKARAM GHOLAMREZA. Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(2):215-220. Available from: https://sid.ir/paper/734161/en

IEEE: Copy

MOHAMMAD KAZEMI ARABABADI, and GHOLAMREZA ASADIKARAM, “Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 2, pp. 215–220, 2016, [Online]. Available: https://sid.ir/paper/734161/en

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