Serological, pathological, and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats

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MOVAHED ALI; Fatemikia Hossein; TANHA KAVEH; ESMAILI ABDOLHAMID; KIM EUIKYUNG; Mohammadpour Dounighi Naser; Zendeboodi Soodabeh; SEYEDIAN RAMIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:12 Page(s): 1221-1225

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Title

Serological, pathological, and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats

Author(s)

Keywords

Envenomation

Fibrin thrombi

Hemiscorpius lepturus

Kidney

Scorpion

Scintigraphy

Abstract

Objective(s): Hemiscorpius lepturus is one of the dangerous Scorpions of Iran leading to acute Kidney injury (AKI) especially in infants. The purpose of this animal study was to compare the serological, pathological and scintigraphic data to quickly predict the occurrence of this disorder. Materials and Methods: In two groups of animals, each contained five rats, H. lepturus venom (1200 μ g/ Kg) were injected intravenously via the tail vein. At three hours and one week later, 99m Tc-DMSA (3 mCi) was intravenously injected and renal Scintigraphy was performed after an hour. Moreover, plasma levels of creatinine, sodium, potassium, and blood urea nitrogen (BUN) were measured. At the end of the study, renal tissues were excised and prepared to perform pathological evaluation after Hematoxylin and Eosin staining. Results: All serological indices were remained unchanged compared to control. A large number of glomerular Fibrin thrombi with entrapped red blood cells and simplified tubular epithelium in dilated and ectatic tubules were observed in high power field (×100) four hours after Envenomation, which reduced significantly one week later. In our scintigraphic study, there was a statistically significant difference (P<0. 05) in Kidney count rate per pixels (CRPP) in both acute and chronic phases compared to the sham group that received normal saline (0. 84± 0. 05 and 1. 36± 0. 07 versus 1. 7± 0. 05). Conclusion: The results of this preliminary animal study suggest renal Scintigraphy is a non-invasive method to predict the occurrence of the AKI in H. lepturus Envenomation. It leads the way for more investigation to counteract the renal failure induced by this venom.

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APA: Copy

MOVAHED, ALI, Fatemikia, Hossein, TANHA, KAVEH, ESMAILI, ABDOLHAMID, KIM, EUIKYUNG, Mohammadpour Dounighi, Naser, Zendeboodi, Soodabeh, & SEYEDIAN, RAMIN. (2018). Serological, pathological, and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(12), 1221-1225. SID. https://sid.ir/paper/734316/en

Vancouver: Copy

MOVAHED ALI, Fatemikia Hossein, TANHA KAVEH, ESMAILI ABDOLHAMID, KIM EUIKYUNG, Mohammadpour Dounighi Naser, Zendeboodi Soodabeh, SEYEDIAN RAMIN. Serological, pathological, and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(12):1221-1225. Available from: https://sid.ir/paper/734316/en

IEEE: Copy

ALI MOVAHED, Hossein Fatemikia, KAVEH TANHA, ABDOLHAMID ESMAILI, EUIKYUNG KIM, Naser Mohammadpour Dounighi, Soodabeh Zendeboodi, and RAMIN SEYEDIAN, “Serological, pathological, and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 12, pp. 1221–1225, 2018, [Online]. Available: https://sid.ir/paper/734316/en

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