COMPARISON OF THE EFFECT OF CO-INJECTION OF ASCORBIC ACID AND D2 AGONIST (BROMOCRIPTINE) WITH ASCORBIC ACID IN NUCLEUS ACCUMBENS SHELL ON MALE RATS' ANXIETY

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NADERI R.; ABBASNEJAD M.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2013 | Volume:15 | Issue:4 Page(s): 100-108

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Title

COMPARISON OF THE EFFECT OF CO-INJECTION OF ASCORBIC ACID AND D2 AGONIST (BROMOCRIPTINE) WITH ASCORBIC ACID IN NUCLEUS ACCUMBENS SHELL ON MALE RATS' ANXIETY

Author(s)

NADERI R. | ABBASNEJAD M. | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ3

NUCLEUS ACCUMBENSQ3

BROMOCRIPTINEQ3

ANXIETYQ2

ELEVATED PLUS MAZEQ2

Abstract

BACKGROUND AND OBJECTIVE: ASCORBIC ACID (AA) is present in the most part of central nervous system (CNS) such as NUCLEUS ACCUMBENS shell (Acbsh). Previous studies have shown that peripheral injection of AA can reduce ANXIETY. So the effect of intra-accumbens injection of AA, BROMOCRIPTINE, and co-administration AA and BROMOCRIPTINE (Br) on ANXIETY behavior of rats were investigated by ELEVATED PLUS MAZE (EPM).METHODS: In this study, 70 adult male Wistar rats (220-270 g) were used in 10 groups: control (intact), sham AA (injected normal saline as AA vehicle), AA (12, 24 and 48 mg/rat/side), sham Br, Br (12.5 and 25 mg/rat/side), AA plus Br (24 and 25 mg/rat), and sham AA plus Br. After surgery and recovery period, drugs were injected (volume=1ml). Thirty minutes after each injection ANXIETY parameters (time percent in open arm and closed arm) were measured for 5 min by EPM task.FINDINGS: The result showed that Intra-accumbens injection of AA (24 mg/side/rat) (223.28±15.24), (48 mg/side/rat) (248.74±12.57) (p<0.001), Br (12.5 mg/side/rat) 235.87±17.45 (p<0.001) and (25 mg/side/rat) 175.57±20.89 (p<0.05) combined injection 228.24±15.99 (p<0.001) significantly increased percentage of time spent in open arm in comparison with control.CONCLUSION: We concluded that intra-accumbens injection of both AA and Br D2 receptor agonist as well as their co-administration induced significant decrease in ANXIETY behavior, dose dependent or dose independent manner.

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APA: Copy

NADERI, R., & ABBASNEJAD, M.. (2013). COMPARISON OF THE EFFECT OF CO-INJECTION OF ASCORBIC ACID AND D₂ AGONIST (BROMOCRIPTINE) WITH ASCORBIC ACID IN NUCLEUS ACCUMBENS SHELL ON MALE RATS' ANXIETY. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 15(4), 100-108. SID. https://sid.ir/paper/73477/en

Vancouver: Copy

NADERI R., ABBASNEJAD M.. COMPARISON OF THE EFFECT OF CO-INJECTION OF ASCORBIC ACID AND D₂ AGONIST (BROMOCRIPTINE) WITH ASCORBIC ACID IN NUCLEUS ACCUMBENS SHELL ON MALE RATS' ANXIETY. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2013;15(4):100-108. Available from: https://sid.ir/paper/73477/en

IEEE: Copy

R. NADERI, and M. ABBASNEJAD, “COMPARISON OF THE EFFECT OF CO-INJECTION OF ASCORBIC ACID AND D₂ AGONIST (BROMOCRIPTINE) WITH ASCORBIC ACID IN NUCLEUS ACCUMBENS SHELL ON MALE RATS' ANXIETY,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 15, no. 4, pp. 100–108, 2013, [Online]. Available: https://sid.ir/paper/73477/en

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