EFFECT OF CO-ADMINISTRATION OF ASCORBIC ACID AND BROMOCRIPTINE IN NUCLEUS ACCUMBENS SHELL ON LOCOMOTOR ACTIVITY IN MALE RATS BY OPEN FIELD TEST

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SHAHSAVARI FATEMEH; ABBASNEJAD MEHDI

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Journal: Physiology and Pharmacology Year:2013 | Volume:17 | Issue:1 Page(s): 126-136

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Information Journal Paper

Title

EFFECT OF CO-ADMINISTRATION OF ASCORBIC ACID AND BROMOCRIPTINE IN NUCLEUS ACCUMBENS SHELL ON LOCOMOTOR ACTIVITY IN MALE RATS BY OPEN FIELD TEST

Author(s)

SHAHSAVARI FATEMEH | ABBASNEJAD MEHDI | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ3

NUCLEUS ACCUMBENS SHELLQ2

BROMOCRIPTINEQ3

LOCOMOTOR ACTIVITYQ2

OPEN FIELD TESTQ2

Abstract

Introduction: ASCORBIC ACID (AA) is present as a vitamin and neuromodulator in most part of the mammalian brain, especially in NUCLEUS ACCUMBENS SHELL (Acbsh), which is one of the important areas controlling motor activity and anxiety. This study evaluates the effect of injection of AA and its co-administration with bromocriptin (Br) in Acbsh on motor activity and anxiety of rats by OPEN FIELD TEST.Methods: Forty nine adult male Wistar rats (220-270 g) were allocated into 7 groups: control (intact), sham AA (normal saline injected as AA vehicle), 3 groups of AA (12, 24 and 48 mg/rat/side), AA plus Br (AA 24 mg/rat/side and Br 25 mg/rat/side), sham AA plus Br. Drugs were injected (volume=1 mL) once, and duration of the test was 5 minutes.Results: Intra-accumbance injection of AA increased LOCOMOTOR ACTIVITY and decreased anxiety. Co-administration of AA and Br resulted in less motor activity and attenuation of Br-induced anxiety.Conclusion: Our results support the previous findings which introduced AA as an effective factor in regulation of LOCOMOTOR ACTIVITY and anxiety in Acbsh, that may be mediated by D2 receptors.

Cites

Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats

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APA: Copy

SHAHSAVARI, FATEMEH, & ABBASNEJAD, MEHDI. (2013). EFFECT OF CO-ADMINISTRATION OF ASCORBIC ACID AND BROMOCRIPTINE IN NUCLEUS ACCUMBENS SHELL ON LOCOMOTOR ACTIVITY IN MALE RATS BY OPEN FIELD TEST. PHYSIOLOGY AND PHARMACOLOGY, 17(1), 126-136. SID. https://sid.ir/paper/75049/en

Vancouver: Copy

SHAHSAVARI FATEMEH, ABBASNEJAD MEHDI. EFFECT OF CO-ADMINISTRATION OF ASCORBIC ACID AND BROMOCRIPTINE IN NUCLEUS ACCUMBENS SHELL ON LOCOMOTOR ACTIVITY IN MALE RATS BY OPEN FIELD TEST. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2013;17(1):126-136. Available from: https://sid.ir/paper/75049/en

IEEE: Copy

FATEMEH SHAHSAVARI, and MEHDI ABBASNEJAD, “EFFECT OF CO-ADMINISTRATION OF ASCORBIC ACID AND BROMOCRIPTINE IN NUCLEUS ACCUMBENS SHELL ON LOCOMOTOR ACTIVITY IN MALE RATS BY OPEN FIELD TEST,” PHYSIOLOGY AND PHARMACOLOGY, vol. 17, no. 1, pp. 126–136, 2013, [Online]. Available: https://sid.ir/paper/75049/en

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